| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DKC1 | DRG1 | ENSP00000358563 | ENSP00000329715 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | Developmentally-regulated GTP-binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | 0.425 |
| DKC1 | FTSJ3 | ENSP00000358563 | ENSP00000396673 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | 0.951 |
| DKC1 | KNOP1 | ENSP00000358563 | ENSP00000219837 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | Lysine rich nucleolar protein 1 | 0.539 |
| DKC1 | RPL7A | ENSP00000358563 | ENSP00000361076 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | Ribosomal protein L7a | 0.637 |
| DKC1 | SHQ1 | ENSP00000358563 | ENSP00000315182 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | Protein SHQ1 homolog; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA | 0.996 |
| DRG1 | DKC1 | ENSP00000329715 | ENSP00000358563 | Developmentally-regulated GTP-binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | 0.425 |
| DRG1 | KNOP1 | ENSP00000329715 | ENSP00000219837 | Developmentally-regulated GTP-binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | Lysine rich nucleolar protein 1 | 0.719 |
| FTSJ3 | DKC1 | ENSP00000396673 | ENSP00000358563 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | 0.951 |
| FTSJ3 | KNOP1 | ENSP00000396673 | ENSP00000219837 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | Lysine rich nucleolar protein 1 | 0.539 |
| FTSJ3 | RPL27 | ENSP00000396673 | ENSP00000464813 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | 60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs | 0.516 |
| FTSJ3 | RPL37A | ENSP00000396673 | ENSP00000418082 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | Ribosomal protein L37a | 0.400 |
| FTSJ3 | RPL7A | ENSP00000396673 | ENSP00000361076 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | Ribosomal protein L7a | 0.608 |
| IQCK | KNOP1 | ENSP00000324901 | ENSP00000219837 | IQ motif containing K | Lysine rich nucleolar protein 1 | 0.635 |
| IQCK | RPL7A | ENSP00000324901 | ENSP00000361076 | IQ motif containing K | Ribosomal protein L7a | 0.505 |
| KNOP1 | DKC1 | ENSP00000219837 | ENSP00000358563 | Lysine rich nucleolar protein 1 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] | 0.539 |
| KNOP1 | DRG1 | ENSP00000219837 | ENSP00000329715 | Lysine rich nucleolar protein 1 | Developmentally-regulated GTP-binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | 0.719 |
| KNOP1 | FTSJ3 | ENSP00000219837 | ENSP00000396673 | Lysine rich nucleolar protein 1 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | 0.539 |
| KNOP1 | IQCK | ENSP00000219837 | ENSP00000324901 | Lysine rich nucleolar protein 1 | IQ motif containing K | 0.635 |
| KNOP1 | NMNAT1 | ENSP00000219837 | ENSP00000366410 | Lysine rich nucleolar protein 1 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.547 |
| KNOP1 | RPL27 | ENSP00000219837 | ENSP00000464813 | Lysine rich nucleolar protein 1 | 60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs | 0.534 |
