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  • 11.0 [archived version]
STRINGSTRING
CDH23 CDH23 OTUD5 OTUD5 RBBP6 RBBP6 USP31 USP31 MRPL27 MRPL27 RPS20 RPS20 MRPL9 MRPL9 MRPL21 MRPL21 MRPL11 MRPL11 MRPL3 MRPL3 MRPL4 MRPL4
"USP31" - Ubiquitin carboxyl-terminal hydrolase 31 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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USP31Ubiquitin carboxyl-terminal hydrolase 31; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity); Belongs to the peptidase C19 family (1352 aa)    
Predicted Functional Partners:
RBBP6
E3 ubiquitin-protein ligase RBBP6; E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10- dependent manner. Controls ZBTB38 protein stability [...] (1792 aa)
      
   
  0.635
OTUD5
OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains. Can also cleave ’Lys-11’- linked ubiquitin chains (in vitro) (571 aa)
      
   
  0.489
MRPL11
Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family (192 aa)
      
 
  0.463
CDH23
Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (1114 aa)
            
  0.455
MRPL4
Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family (311 aa)
      
 
  0.442
MRPL3
Mitochondrial ribosomal protein L3 (348 aa)
      
 
  0.436
MRPL21
Mitochondrial ribosomal protein L21 (205 aa)
      
 
  0.434
MRPL9
Mitochondrial ribosomal protein L9 (267 aa)
      
      0.430
RPS20
Ribosomal protein S20 (142 aa)
      
 
  0.429
MRPL27
Mitochondrial ribosomal protein L27 (148 aa)
      
 
  0.415
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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