node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C5 | WFDC1 | ENSP00000223642 | ENSP00000219454 | Complement C5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled; C3 and PZP like, alpha-2-macroglobulin domain containing | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | 0.641 |
KLHDC4 | WFDC1 | ENSP00000270583 | ENSP00000219454 | Kelch domain containing 4 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | 0.561 |
NMI | WFDC1 | ENSP00000243346 | ENSP00000219454 | N-myc-interactor; May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5; Belongs to the NMI family | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | 0.558 |
OSMR | WFDC1 | ENSP00000274276 | ENSP00000219454 | Oncostatin-M-specific receptor subunit beta; Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events; Fibronectin type III domain containing | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | 0.558 |
QPCT | SLPI | ENSP00000344829 | ENSP00000342082 | Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...] | 0.902 |
QPCT | WFDC1 | ENSP00000344829 | ENSP00000219454 | Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | 0.535 |
SLPI | QPCT | ENSP00000342082 | ENSP00000344829 | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...] | Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | 0.902 |
SLPI | WFDC1 | ENSP00000342082 | ENSP00000219454 | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...] | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | 0.542 |
SLPI | WFDC2 | ENSP00000342082 | ENSP00000361761 | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...] | WAP four-disulfide core domain protein 2; Broad range protease inhibitor; WAP four-disulfide core domain containing | 0.614 |
TGM2 | WFDC1 | ENSP00000355330 | ENSP00000219454 | Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Transglutaminases | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | 0.497 |
WFDC1 | C5 | ENSP00000219454 | ENSP00000223642 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | Complement C5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled; C3 and PZP like, alpha-2-macroglobulin domain containing | 0.641 |
WFDC1 | KLHDC4 | ENSP00000219454 | ENSP00000270583 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | Kelch domain containing 4 | 0.561 |
WFDC1 | NMI | ENSP00000219454 | ENSP00000243346 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | N-myc-interactor; May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5; Belongs to the NMI family | 0.558 |
WFDC1 | OSMR | ENSP00000219454 | ENSP00000274276 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | Oncostatin-M-specific receptor subunit beta; Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events; Fibronectin type III domain containing | 0.558 |
WFDC1 | QPCT | ENSP00000219454 | ENSP00000344829 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | 0.535 |
WFDC1 | SLPI | ENSP00000219454 | ENSP00000342082 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...] | 0.542 |
WFDC1 | TGM2 | ENSP00000219454 | ENSP00000355330 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Transglutaminases | 0.497 |
WFDC1 | WFDC11 | ENSP00000219454 | ENSP00000348968 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | Protein WFDC11; WAP four-disulfide core domain containing | 0.481 |
WFDC1 | WFDC2 | ENSP00000219454 | ENSP00000361761 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | WAP four-disulfide core domain protein 2; Broad range protease inhibitor; WAP four-disulfide core domain containing | 0.486 |
WFDC1 | WFDC5 | ENSP00000219454 | ENSP00000361875 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | 0.465 |