| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AANAT | ASMT | ENSP00000250615 | ENSP00000370639 | Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin; Belongs to the acetyltransferase family. AANAT subfamily | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity; Pseudoautosomal region 1 | 0.992 |
| AANAT | GPR50 | ENSP00000250615 | ENSP00000218316 | Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin; Belongs to the acetyltransferase family. AANAT subfamily | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | 0.562 |
| AANAT | MTNR1A | ENSP00000250615 | ENSP00000302811 | Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin; Belongs to the acetyltransferase family. AANAT subfamily | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family | 0.770 |
| AANAT | MTNR1B | ENSP00000250615 | ENSP00000257068 | Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin; Belongs to the acetyltransferase family. AANAT subfamily | Melatonin receptor type 1B; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family | 0.735 |
| ASMT | AANAT | ENSP00000370639 | ENSP00000250615 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity; Pseudoautosomal region 1 | Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin; Belongs to the acetyltransferase family. AANAT subfamily | 0.992 |
| ASMT | GPR50 | ENSP00000370639 | ENSP00000218316 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity; Pseudoautosomal region 1 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | 0.558 |
| ASMT | MTNR1A | ENSP00000370639 | ENSP00000302811 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity; Pseudoautosomal region 1 | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family | 0.763 |
| ASMT | MTNR1B | ENSP00000370639 | ENSP00000257068 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity; Pseudoautosomal region 1 | Melatonin receptor type 1B; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family | 0.732 |
| C2orf42 | GPR50 | ENSP00000264434 | ENSP00000218316 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | 0.545 |
| F9 | GPR50 | ENSP00000218099 | ENSP00000218316 | Coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | 0.551 |
| GPR50 | AANAT | ENSP00000218316 | ENSP00000250615 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin; Belongs to the acetyltransferase family. AANAT subfamily | 0.562 |
| GPR50 | ASMT | ENSP00000218316 | ENSP00000370639 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity; Pseudoautosomal region 1 | 0.558 |
| GPR50 | C2orf42 | ENSP00000218316 | ENSP00000264434 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42 | 0.545 |
| GPR50 | F9 | ENSP00000218316 | ENSP00000218099 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family | 0.551 |
| GPR50 | KRT74 | ENSP00000218316 | ENSP00000307240 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type II | 0.624 |
| GPR50 | MTNR1A | ENSP00000218316 | ENSP00000302811 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family | 0.869 |
| GPR50 | MTNR1B | ENSP00000218316 | ENSP00000257068 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Melatonin receptor type 1B; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family | 0.870 |
| GPR50 | NPVF | ENSP00000218316 | ENSP00000222674 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Pro-FMRFamide-related neuropeptide VF; Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine- induced analgesia; Belongs to the FARP (FMRFamide related peptide) family | 0.626 |
| GPR50 | RBP1 | ENSP00000218316 | ENSP00000232219 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Retinol-binding protein 1; Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family | 0.531 |
| GPR50 | SLC16A2 | ENSP00000218316 | ENSP00000465734 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family | 0.541 |
