| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHGA | CHGB | ENSP00000216492 | ENSP00000368244 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.943 |
| CHGA | CPE | ENSP00000216492 | ENSP00000386104 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | 0.648 |
| CHGA | PCSK1 | ENSP00000216492 | ENSP00000308024 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Neuroendocrine convertase 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP; Belongs to the peptidase S8 family. Furin subfamily | 0.596 |
| CHGA | PCSK1N | ENSP00000216492 | ENSP00000218230 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | ProSAAS; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timi [...] | 0.608 |
| CHGA | SCG2 | ENSP00000216492 | ENSP00000304133 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Secretogranin-2; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides; Granins | 0.860 |
| CHGA | SCG3 | ENSP00000216492 | ENSP00000220478 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Secretogranin-3; Secretogranin III; Granins | 0.979 |
| CHGA | SCG5 | ENSP00000216492 | ENSP00000300175 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro; Granins | 0.669 |
| CHGA | VGF | ENSP00000216492 | ENSP00000249330 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | Neurosecretory protein VGF; May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system; Granins | 0.578 |
| CHGB | CHGA | ENSP00000368244 | ENSP00000216492 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | 0.943 |
| CHGB | CPE | ENSP00000368244 | ENSP00000386104 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | 0.624 |
| CHGB | PCSK1 | ENSP00000368244 | ENSP00000308024 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Neuroendocrine convertase 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP; Belongs to the peptidase S8 family. Furin subfamily | 0.605 |
| CHGB | PCSK1N | ENSP00000368244 | ENSP00000218230 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | ProSAAS; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timi [...] | 0.724 |
| CHGB | SCG2 | ENSP00000368244 | ENSP00000304133 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Secretogranin-2; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides; Granins | 0.992 |
| CHGB | SCG3 | ENSP00000368244 | ENSP00000220478 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Secretogranin-3; Secretogranin III; Granins | 0.979 |
| CHGB | SCG5 | ENSP00000368244 | ENSP00000300175 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro; Granins | 0.845 |
| CHGB | VGF | ENSP00000368244 | ENSP00000249330 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Neurosecretory protein VGF; May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system; Granins | 0.968 |
| CPE | CHGA | ENSP00000386104 | ENSP00000216492 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | 0.648 |
| CPE | CHGB | ENSP00000386104 | ENSP00000368244 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.624 |
| CPE | PCSK1 | ENSP00000386104 | ENSP00000308024 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | Neuroendocrine convertase 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP; Belongs to the peptidase S8 family. Furin subfamily | 0.713 |
| CPE | PCSK1N | ENSP00000386104 | ENSP00000218230 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family | ProSAAS; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timi [...] | 0.783 |
