• Version:
  • 11.0 [archived version]
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FAU FAU KCNIP3 KCNIP3 VSNL1 VSNL1 KCNIP1 KCNIP1 KCNIP2 KCNIP2 KCNN4 KCNN4 KCND1 KCND1 KCNIP4 KCNIP4 KCNAB3 KCNAB3 KCNAB1 KCNAB1 KCNAB2 KCNAB2
"KCND1" - Potassium voltage-gated channel subfamily D member 1 in Homo sapiens
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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KCND1Potassium voltage-gated channel subfamily D member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits; Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily (647 aa)    
Predicted Functional Partners:
KCNIP1
Potassium voltage-gated channel interacting protein 1; EF-hand domain containing (241 aa)
     
  0.995
KCNIP4
Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family (250 aa)
     
  0.982
KCNIP2
Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity); EF-hand domain containing (285 aa)
     
  0.977
KCNIP3
Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity); EF-hand domain containing (256 aa)
     
  0.972
KCNAB2
Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5 [...] (415 aa)
     
  0.964
KCNAB1
Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the clos [...] (419 aa)
     
  0.961
KCNAB3
Voltage-gated potassium channel subunit beta-3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5; Aldo-keto reductases (404 aa)
     
  0.953
FAU
Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion (133 aa)
     
 
  0.788
VSNL1
Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family (191 aa)
     
 
  0.769
KCNN4
Intermediate conductance calcium-activated potassium channel protein 4; Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin; Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily (427 aa)
     
   
  0.766
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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