node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CXorf56 | SLC25A43 | ENSP00000441786 | ENSP00000217909 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.636 |
DOCK11 | RNF113A | ENSP00000276202 | ENSP00000360497 | Dedicator of cytokinesis protein 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42; Belongs to the DOCK family | RING finger protein 113A; Spliceosomal Bact complex; Ring finger proteins | 0.535 |
DOCK11 | SEPT6 | ENSP00000276202 | ENSP00000341524 | Dedicator of cytokinesis protein 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42; Belongs to the DOCK family | Septin-6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation; Septins | 0.636 |
DOCK11 | SLC25A43 | ENSP00000276202 | ENSP00000217909 | Dedicator of cytokinesis protein 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42; Belongs to the DOCK family | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.627 |
FRMD7 | GPR112 | ENSP00000298542 | ENSP00000377699 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.514 |
FRMD7 | MAP3K15 | ENSP00000298542 | ENSP00000345629 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | 0.624 |
FRMD7 | SLC25A43 | ENSP00000298542 | ENSP00000217909 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.637 |
GPR112 | FRMD7 | ENSP00000377699 | ENSP00000298542 | Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | 0.514 |
GPR112 | MAP3K15 | ENSP00000377699 | ENSP00000345629 | Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | 0.565 |
GPR112 | SLC25A43 | ENSP00000377699 | ENSP00000217909 | Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.654 |
GPR112 | ZNF280C | ENSP00000377699 | ENSP00000360017 | Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Zinc finger protein 280C; May function as a transcription factor | 0.623 |
HDHD1 | SLC25A43 | ENSP00000396452 | ENSP00000217909 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.549 |
HDHD1 | ZNF280C | ENSP00000396452 | ENSP00000360017 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | Zinc finger protein 280C; May function as a transcription factor | 0.496 |
MAP3K15 | FRMD7 | ENSP00000345629 | ENSP00000298542 | Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | 0.624 |
MAP3K15 | GPR112 | ENSP00000345629 | ENSP00000377699 | Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.565 |
MAP3K15 | SLC25A43 | ENSP00000345629 | ENSP00000217909 | Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.684 |
NUP62CL | SLC25A43 | ENSP00000361544 | ENSP00000217909 | Nucleoporin-62 C-terminal-like protein; Nucleoporin 62 C-terminal like; Belongs to the nucleoporin NSP1/NUP62 family | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.590 |
RNF113A | DOCK11 | ENSP00000360497 | ENSP00000276202 | RING finger protein 113A; Spliceosomal Bact complex; Ring finger proteins | Dedicator of cytokinesis protein 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42; Belongs to the DOCK family | 0.535 |
RNF113A | SEPT6 | ENSP00000360497 | ENSP00000341524 | RING finger protein 113A; Spliceosomal Bact complex; Ring finger proteins | Septin-6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation; Septins | 0.701 |
RNF113A | SLC25A43 | ENSP00000360497 | ENSP00000217909 | RING finger protein 113A; Spliceosomal Bact complex; Ring finger proteins | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.751 |