node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GAD1 | GAD2 | ENSP00000350928 | ENSP00000365437 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.956 |
GAD1 | RAB3A | ENSP00000350928 | ENSP00000222256 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Ras-related protein Rab-3A; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal; RAB, member RAS oncogene GTPases | 0.945 |
GAD1 | SLC17A6 | ENSP00000350928 | ENSP00000263160 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | 0.843 |
GAD1 | SLC17A7 | ENSP00000350928 | ENSP00000221485 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | 0.849 |
GAD1 | SLC17A8 | ENSP00000350928 | ENSP00000316909 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | 0.651 |
GAD1 | SLC18A3 | ENSP00000350928 | ENSP00000363229 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | 0.727 |
GAD1 | SLC32A1 | ENSP00000350928 | ENSP00000217420 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.999 |
GAD1 | SNAP25 | ENSP00000350928 | ENSP00000254976 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.959 |
GAD1 | SYT1 | ENSP00000350928 | ENSP00000261205 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.949 |
GAD1 | VAMP2 | ENSP00000350928 | ENSP00000314214 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1; Belongs to the synaptobrevin family | 0.923 |
GAD2 | GAD1 | ENSP00000365437 | ENSP00000350928 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 0.956 |
GAD2 | RAB3A | ENSP00000365437 | ENSP00000222256 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Ras-related protein Rab-3A; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal; RAB, member RAS oncogene GTPases | 0.933 |
GAD2 | SLC17A6 | ENSP00000365437 | ENSP00000263160 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | 0.860 |
GAD2 | SLC17A7 | ENSP00000365437 | ENSP00000221485 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | 0.856 |
GAD2 | SLC17A8 | ENSP00000365437 | ENSP00000316909 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | 0.593 |
GAD2 | SLC18A3 | ENSP00000365437 | ENSP00000363229 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | 0.659 |
GAD2 | SLC32A1 | ENSP00000365437 | ENSP00000217420 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.994 |
GAD2 | SNAP25 | ENSP00000365437 | ENSP00000254976 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.967 |
GAD2 | SYT1 | ENSP00000365437 | ENSP00000261205 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.957 |
GAD2 | VAMP2 | ENSP00000365437 | ENSP00000314214 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1; Belongs to the synaptobrevin family | 0.947 |