node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAK1 | ARF6 | ENSP00000386456 | ENSP00000298316 | AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to [...] | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | 0.916 |
AAK1 | TLDC2 | ENSP00000386456 | ENSP00000217320 | AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to [...] | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.617 |
ARF6 | AAK1 | ENSP00000298316 | ENSP00000386456 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to [...] | 0.916 |
ARF6 | TLDC2 | ENSP00000298316 | ENSP00000217320 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.498 |
FREM3 | TLDC2 | ENSP00000332886 | ENSP00000217320 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.541 |
LAMB4 | TLDC2 | ENSP00000373433 | ENSP00000217320 | Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.479 |
OR4C13 | TLDC2 | ENSP00000452277 | ENSP00000217320 | Olfactory receptor 4C13; Odorant receptor; Olfactory receptors, family 4 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.559 |
OR51H1P | TLDC2 | ENSP00000322724 | ENSP00000217320 | Olfactory receptor 51H1; Odorant receptor | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.543 |
OR6N2 | TLDC2 | ENSP00000344101 | ENSP00000217320 | Olfactory receptor 6N2; Odorant receptor; Olfactory receptors, family 6 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.554 |
OR9K2 | TLDC2 | ENSP00000307598 | ENSP00000217320 | Olfactory receptor 9K2; Odorant receptor; Olfactory receptors, family 9 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.532 |
RAB3GAP2 | TLDC2 | ENSP00000351832 | ENSP00000217320 | Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.482 |
RAD21L1 | TLDC2 | ENSP00000386414 | ENSP00000217320 | Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity) | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | 0.514 |
TLDC2 | AAK1 | ENSP00000217320 | ENSP00000386456 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to [...] | 0.617 |
TLDC2 | ARF6 | ENSP00000217320 | ENSP00000298316 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | 0.498 |
TLDC2 | FREM3 | ENSP00000217320 | ENSP00000332886 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | 0.541 |
TLDC2 | LAMB4 | ENSP00000217320 | ENSP00000373433 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.479 |
TLDC2 | OR4C13 | ENSP00000217320 | ENSP00000452277 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | Olfactory receptor 4C13; Odorant receptor; Olfactory receptors, family 4 | 0.559 |
TLDC2 | OR51H1P | ENSP00000217320 | ENSP00000322724 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | Olfactory receptor 51H1; Odorant receptor | 0.543 |
TLDC2 | OR6N2 | ENSP00000217320 | ENSP00000344101 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | Olfactory receptor 6N2; Odorant receptor; Olfactory receptors, family 6 | 0.554 |
TLDC2 | OR9K2 | ENSP00000217320 | ENSP00000307598 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family | Olfactory receptor 9K2; Odorant receptor; Olfactory receptors, family 9 | 0.532 |