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STRINGSTRING
ARF6 ARF6 OR9K2 OR9K2 AAK1 AAK1 OR4C13 OR4C13 RAB3GAP2 RAB3GAP2 TLDC2 TLDC2 LAMB4 LAMB4 RAD21L1 RAD21L1 FREM3 FREM3 OR6N2 OR6N2 OR51H1P OR51H1P
"TLDC2" - TLD domain-containing protein 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TLDC2TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family (215 aa)    
Predicted Functional Partners:
AAK1
AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to [...] (961 aa)
      
   
  0.617
OR4C13
Olfactory receptor 4C13; Odorant receptor; Olfactory receptors, family 4 (309 aa)
            
  0.559
OR6N2
Olfactory receptor 6N2; Odorant receptor; Olfactory receptors, family 6 (317 aa)
            
  0.554
OR51H1P
Olfactory receptor 51H1; Odorant receptor (302 aa)
            
  0.543
FREM3
FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion (2139 aa)
      
   
  0.541
OR9K2
Olfactory receptor 9K2; Odorant receptor; Olfactory receptors, family 9 (335 aa)
            
  0.532
RAD21L1
Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity) (556 aa)
      
   
  0.514
ARF6
ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] (175 aa)
      
   
  0.498
RAB3GAP2
Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters (1393 aa)
      
   
  0.482
LAMB4
Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (1761 aa)
            
  0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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