node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMBRA1 | C20orf27 | ENSP00000431926 | ENSP00000217195 | Activating molecule in BECN1-regulated autophagy protein 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity); DDB1 and CUL4 associated factors | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | 0.533 |
AMBRA1 | PSME3 | ENSP00000431926 | ENSP00000293362 | Activating molecule in BECN1-regulated autophagy protein 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity); DDB1 and CUL4 associated factors | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] | 0.487 |
ATAD3B | C20orf27 | ENSP00000311766 | ENSP00000217195 | ATPase family AAA domain-containing protein 3B; May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes; AAA ATPases | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | 0.491 |
ATAD3B | QSER1 | ENSP00000311766 | ENSP00000382241 | ATPase family AAA domain-containing protein 3B; May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes; AAA ATPases | Glutamine and serine rich 1 | 0.429 |
C20orf27 | AMBRA1 | ENSP00000217195 | ENSP00000431926 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Activating molecule in BECN1-regulated autophagy protein 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity); DDB1 and CUL4 associated factors | 0.533 |
C20orf27 | ATAD3B | ENSP00000217195 | ENSP00000311766 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | ATPase family AAA domain-containing protein 3B; May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes; AAA ATPases | 0.491 |
C20orf27 | DMWD | ENSP00000217195 | ENSP00000270223 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Dystrophia myotonica WD repeat-containing protein; DM1 locus, WD repeat containing | 0.747 |
C20orf27 | LETMD1 | ENSP00000217195 | ENSP00000389903 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.471 |
C20orf27 | PPP1CA | ENSP00000217195 | ENSP00000326031 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.657 |
C20orf27 | PPP1CC | ENSP00000217195 | ENSP00000341779 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] | 0.668 |
C20orf27 | PRPF38A | ENSP00000217195 | ENSP00000257181 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | 0.473 |
C20orf27 | PSME3 | ENSP00000217195 | ENSP00000293362 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] | 0.684 |
C20orf27 | QSER1 | ENSP00000217195 | ENSP00000382241 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Glutamine and serine rich 1 | 0.573 |
C20orf27 | RBFOX2 | ENSP00000217195 | ENSP00000413035 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Prevents binding of U2AF2 to the 3’-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha | 0.637 |
DMWD | C20orf27 | ENSP00000270223 | ENSP00000217195 | Dystrophia myotonica WD repeat-containing protein; DM1 locus, WD repeat containing | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | 0.747 |
DMWD | PSME3 | ENSP00000270223 | ENSP00000293362 | Dystrophia myotonica WD repeat-containing protein; DM1 locus, WD repeat containing | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] | 0.581 |
DMWD | RBFOX2 | ENSP00000270223 | ENSP00000413035 | Dystrophia myotonica WD repeat-containing protein; DM1 locus, WD repeat containing | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Prevents binding of U2AF2 to the 3’-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha | 0.524 |
LETMD1 | C20orf27 | ENSP00000389903 | ENSP00000217195 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | 0.471 |
LETMD1 | QSER1 | ENSP00000389903 | ENSP00000382241 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | Glutamine and serine rich 1 | 0.400 |
PPP1CA | C20orf27 | ENSP00000326031 | ENSP00000217195 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | 0.657 |