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  • 11.0 [archived version]
STRINGSTRING
ZNF568 ZNF568 DOK1 DOK1 PTK6 PTK6 SNX8 SNX8 SRMS SRMS FAM102A FAM102A KIFC3 KIFC3 STK31 STK31 GMEB2 GMEB2 SMCHD1 SMCHD1 TBRG4 TBRG4
"SRMS" - Tyrosine-protein kinase Srms in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SRMSTyrosine-protein kinase Srms; Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin; SH2 domain containing (488 aa)    
Predicted Functional Partners:
PTK6
Protein-tyrosine kinase 6; Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins- KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors- STAT3 and STAT5A/B and a variety of signaling molecule [...] (451 aa)
     
 
0.910
STK31
Serine/threonine kinase 31; Tudor domain containing (1019 aa)
           
  0.686
TBRG4
Protein TBRG4; May play a role in cell cycle progression; FASTK mitochondrial RNA binding family (631 aa)
           
  0.676
DOK1
Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (481 aa)
       
 
  0.596
SNX8
Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network; PX-BAR domain containing (465 aa)
       
 
  0.590
KIFC3
Kinesin-like protein KIFC3; Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family (833 aa)
     
 
  0.587
SMCHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells (2005 aa)
           
  0.552
ZNF568
Zinc finger protein 568; Has transcriptional repression activity, partially through the recuitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance pr [...] (644 aa)
     
 
  0.524
GMEB2
Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses (530 aa)
           
  0.523
FAM102A
Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family (384 aa)
     
   
  0.519
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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