| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABHD5 | TPD52L2 | ENSP00000390849 | ENSP00000217121 | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion (By similarity); Abhydrolase domain containing | Tumor protein D52 like 2 | 0.817 |
| ADCK3 | SH3GLB1 | ENSP00000355741 | ENSP00000479919 | Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear- does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by a [...] | 0.714 |
| ADCK3 | TPD52L2 | ENSP00000355741 | ENSP00000217121 | Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear- does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP | Tumor protein D52 like 2 | 0.795 |
| GABPA | GABPB1 | ENSP00000346886 | ENSP00000220429 | GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Belongs to the ETS family | GA-binding protein subunit beta-1; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Ankyrin repeat domain containing | 0.993 |
| GABPA | TPD52L2 | ENSP00000346886 | ENSP00000217121 | GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Belongs to the ETS family | Tumor protein D52 like 2 | 0.823 |
| GABPB1 | GABPA | ENSP00000220429 | ENSP00000346886 | GA-binding protein subunit beta-1; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Ankyrin repeat domain containing | GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Belongs to the ETS family | 0.993 |
| GABPB1 | TPD52L2 | ENSP00000220429 | ENSP00000217121 | GA-binding protein subunit beta-1; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Ankyrin repeat domain containing | Tumor protein D52 like 2 | 0.859 |
| KIF1A | TPD52L2 | ENSP00000438388 | ENSP00000217121 | Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily | Tumor protein D52 like 2 | 0.641 |
| KIF1A | ZMYND8 | ENSP00000438388 | ENSP00000420095 | Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily | Protein kinase C-binding protein 1; May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis- associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion; Bromodomain containing | 0.476 |
| MAL2 | TPD52 | ENSP00000479708 | ENSP00000429309 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway | Tumor protein D52 | 0.930 |
| MAL2 | TPD52L2 | ENSP00000479708 | ENSP00000217121 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway | Tumor protein D52 like 2 | 0.872 |
| MALL | TPD52 | ENSP00000272462 | ENSP00000429309 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Tumor protein D52 | 0.574 |
| MALL | TPD52L2 | ENSP00000272462 | ENSP00000217121 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Tumor protein D52 like 2 | 0.757 |
| SH3GLB1 | ADCK3 | ENSP00000479919 | ENSP00000355741 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by a [...] | Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear- does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP | 0.714 |
| SH3GLB1 | TPD52L2 | ENSP00000479919 | ENSP00000217121 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by a [...] | Tumor protein D52 like 2 | 0.798 |
| TPD52 | MAL2 | ENSP00000429309 | ENSP00000479708 | Tumor protein D52 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway | 0.930 |
| TPD52 | MALL | ENSP00000429309 | ENSP00000272462 | Tumor protein D52 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | 0.574 |
| TPD52 | TPD52L2 | ENSP00000429309 | ENSP00000217121 | Tumor protein D52 | Tumor protein D52 like 2 | 0.703 |
| TPD52L2 | ABHD5 | ENSP00000217121 | ENSP00000390849 | Tumor protein D52 like 2 | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion (By similarity); Abhydrolase domain containing | 0.817 |
| TPD52L2 | ADCK3 | ENSP00000217121 | ENSP00000355741 | Tumor protein D52 like 2 | Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear- does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP | 0.795 |
