• Version:
  • 11.0 [archived version]
STRINGSTRING
GPX5 GPX5 GPX2 GPX2 GSR GSR GGT5 GGT5 GGT7 GGT7 GGT6 GGT6 GCLM GCLM GSS GSS GCLC GCLC GPX1 GPX1 GPX4 GPX4
"GSS" - Glutathione synthetase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GSSGlutathione synthetase; Belongs to the eukaryotic GSH synthase family (474 aa)    
Predicted Functional Partners:
GCLC
Glutamate-cysteine ligase catalytic subunit (637 aa)
     
  0.986
GSR
Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol (522 aa)
     
 
  0.985
GCLM
Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily (274 aa)
     
 
  0.974
GPX1
Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown; Belongs to the glutathione peroxidase family (203 aa)
     
 
  0.954
GPX5
Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids (221 aa)
         
  0.951
GPX4
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] (197 aa)
         
  0.951
GGT6
Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases (499 aa)
     
 
  0.949
GPX2
Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors; Selenoproteins (190 aa)
         
  0.949
GGT7
Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases (662 aa)
     
 
  0.949
GGT5
Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family (587 aa)
     
 
  0.946
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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