node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GCLC | GCLM | ENSP00000229416 | ENSP00000359258 | Glutamate-cysteine ligase catalytic subunit | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | 0.999 |
GCLC | GGT5 | ENSP00000229416 | ENSP00000381340 | Glutamate-cysteine ligase catalytic subunit | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.928 |
GCLC | GGT6 | ENSP00000229416 | ENSP00000370962 | Glutamate-cysteine ligase catalytic subunit | Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.933 |
GCLC | GGT7 | ENSP00000229416 | ENSP00000338964 | Glutamate-cysteine ligase catalytic subunit | Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.931 |
GCLC | GPX1 | ENSP00000229416 | ENSP00000407375 | Glutamate-cysteine ligase catalytic subunit | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown; Belongs to the glutathione peroxidase family | 0.760 |
GCLC | GPX2 | ENSP00000229416 | ENSP00000374265 | Glutamate-cysteine ligase catalytic subunit | Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors; Selenoproteins | 0.709 |
GCLC | GPX4 | ENSP00000229416 | ENSP00000346103 | Glutamate-cysteine ligase catalytic subunit | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] | 0.754 |
GCLC | GPX5 | ENSP00000229416 | ENSP00000392398 | Glutamate-cysteine ligase catalytic subunit | Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids | 0.499 |
GCLC | GSR | ENSP00000229416 | ENSP00000221130 | Glutamate-cysteine ligase catalytic subunit | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol | 0.899 |
GCLC | GSS | ENSP00000229416 | ENSP00000216951 | Glutamate-cysteine ligase catalytic subunit | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family | 0.986 |
GCLM | GCLC | ENSP00000359258 | ENSP00000229416 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutamate-cysteine ligase catalytic subunit | 0.999 |
GCLM | GGT5 | ENSP00000359258 | ENSP00000381340 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.918 |
GCLM | GGT6 | ENSP00000359258 | ENSP00000370962 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.902 |
GCLM | GGT7 | ENSP00000359258 | ENSP00000338964 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases | 0.903 |
GCLM | GPX1 | ENSP00000359258 | ENSP00000407375 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown; Belongs to the glutathione peroxidase family | 0.650 |
GCLM | GPX2 | ENSP00000359258 | ENSP00000374265 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors; Selenoproteins | 0.619 |
GCLM | GPX4 | ENSP00000359258 | ENSP00000346103 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] | 0.543 |
GCLM | GPX5 | ENSP00000359258 | ENSP00000392398 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids | 0.427 |
GCLM | GSR | ENSP00000359258 | ENSP00000221130 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol | 0.758 |
GCLM | GSS | ENSP00000359258 | ENSP00000216951 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family | 0.974 |