node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | BDKRB1 | ENSP00000355627 | ENSP00000216629 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | 0.944 |
AGT | BDKRB2 | ENSP00000355627 | ENSP00000450482 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily | 0.933 |
AGT | CHRM4 | ENSP00000355627 | ENSP00000409378 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Cholinergic receptors muscarinic | 0.902 |
AGT | EDN1 | ENSP00000355627 | ENSP00000368683 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 0.981 |
AGT | GNAQ | ENSP00000355627 | ENSP00000286548 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity); Belongs to the G-alpha family. G(q) subfamily | 0.917 |
AGT | GNG4 | ENSP00000355627 | ENSP00000375727 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.903 |
AGT | KNG1 | ENSP00000355627 | ENSP00000265023 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Kininogen-1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.974 |
AGT | NMB | ENSP00000355627 | ENSP00000378089 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | 0.906 |
AGT | NTS | ENSP00000355627 | ENSP00000256010 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family | 0.933 |
AGT | TAC1 | ENSP00000355627 | ENSP00000321106 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Protachykinin-1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Endogenous ligands | 0.929 |
BDKRB1 | AGT | ENSP00000216629 | ENSP00000355627 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | 0.944 |
BDKRB1 | BDKRB2 | ENSP00000216629 | ENSP00000450482 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily | 0.938 |
BDKRB1 | CHRM4 | ENSP00000216629 | ENSP00000409378 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Cholinergic receptors muscarinic | 0.925 |
BDKRB1 | EDN1 | ENSP00000216629 | ENSP00000368683 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 0.928 |
BDKRB1 | GNAQ | ENSP00000216629 | ENSP00000286548 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity); Belongs to the G-alpha family. G(q) subfamily | 0.955 |
BDKRB1 | GNG4 | ENSP00000216629 | ENSP00000375727 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.931 |
BDKRB1 | KNG1 | ENSP00000216629 | ENSP00000265023 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Kininogen-1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.992 |
BDKRB1 | NMB | ENSP00000216629 | ENSP00000378089 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | 0.921 |
BDKRB1 | NTS | ENSP00000216629 | ENSP00000256010 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family | 0.923 |
BDKRB1 | TAC1 | ENSP00000216629 | ENSP00000321106 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | Protachykinin-1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Endogenous ligands | 0.919 |