DHRS7 protein (human) - STRING database

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DHRS7

Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily (339 aa)

Predicted Functional Partners:

TMEM38A

0.762

TMEM126A

0.746

C17orf62

0.716

TMTC3

0.646

POPDC2

0.598

KIAA0247

0.578

HAO2

0.575

TMEM201

0.565

TMEM199

0.559

TMEM209

0.501

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C17orf62	DHRS7	ENSP00000388909	ENSP00000216500	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	0.716
C17orf62	POPDC2	ENSP00000388909	ENSP00000264231	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family	0.536
C17orf62	TMEM126A	ENSP00000388909	ENSP00000306887	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Transmembrane protein 126A; Belongs to the TMEM126 family	0.765
C17orf62	TMEM199	ENSP00000388909	ENSP00000292114	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis	0.730
C17orf62	TMEM201	ENSP00000388909	ENSP00000344503	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery	0.555
C17orf62	TMEM209	ENSP00000388909	ENSP00000380747	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Transmembrane protein 209	0.668
C17orf62	TMEM38A	ENSP00000388909	ENSP00000187762	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores	0.709
C17orf62	TMTC3	ENSP00000388909	ENSP00000266712	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing	0.621
DHRS7	C17orf62	ENSP00000216500	ENSP00000388909	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62	0.716
DHRS7	HAO2	ENSP00000216500	ENSP00000483507	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family	0.575
DHRS7	KIAA0247	ENSP00000216500	ENSP00000344424	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Sushi domain-containing protein 6; May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. Plays a role in preventing tumor onset (By similarity)	0.578
DHRS7	POPDC2	ENSP00000216500	ENSP00000264231	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family	0.598
DHRS7	TMEM126A	ENSP00000216500	ENSP00000306887	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Transmembrane protein 126A; Belongs to the TMEM126 family	0.746
DHRS7	TMEM199	ENSP00000216500	ENSP00000292114	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis	0.559
DHRS7	TMEM201	ENSP00000216500	ENSP00000344503	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery	0.565
DHRS7	TMEM209	ENSP00000216500	ENSP00000380747	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Transmembrane protein 209	0.501
DHRS7	TMEM38A	ENSP00000216500	ENSP00000187762	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores	0.762
DHRS7	TMTC3	ENSP00000216500	ENSP00000266712	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing	0.646
HAO2	DHRS7	ENSP00000483507	ENSP00000216500	Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	0.575
KIAA0247	DHRS7	ENSP00000344424	ENSP00000216500	Sushi domain-containing protein 6; May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. Plays a role in preventing tumor onset (By similarity)	Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily	0.578

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