CGRRF1 protein (human) - STRING database

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CGRRF1

Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins (332 aa)

Predicted Functional Partners:

CGREF1

0.931

RNF170

0.725

RNFT1

0.659

RNF185

0.657

PLXDC2

0.653

RNF121

0.602

RNF130

0.580

RNF180

0.576

SERAC1

0.574

RNF145

0.573

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGREF1	CGRRF1	ENSP00000385452	ENSP00000216420	Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines; EF-hand domain containing	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	0.931
CGRRF1	CGREF1	ENSP00000216420	ENSP00000385452	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines; EF-hand domain containing	0.931
CGRRF1	PLXDC2	ENSP00000216420	ENSP00000366460	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	0.653
CGRRF1	RNF121	ENSP00000216420	ENSP00000354571	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	Ring finger protein 121; Belongs to the RNF121 family	0.602
CGRRF1	RNF130	ENSP00000216420	ENSP00000430237	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase; Ring finger proteins	0.580
CGRRF1	RNF145	ENSP00000216420	ENSP00000430955	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	Ring finger protein 145	0.573
CGRRF1	RNF170	ENSP00000216420	ENSP00000445725	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells; Ring finger proteins	0.725
CGRRF1	RNF180	ENSP00000216420	ENSP00000373752	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2; Ring finger proteins	0.576
CGRRF1	RNF185	ENSP00000216420	ENSP00000320508	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating ’Lys-63’-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...]	0.657
CGRRF1	RNFT1	ENSP00000216420	ENSP00000304670	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis; Ring finger proteins	0.659
CGRRF1	SERAC1	ENSP00000216420	ENSP00000356071	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36-1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway; Armadillo-like helical domain containing	0.574
PLXDC2	CGRRF1	ENSP00000366460	ENSP00000216420	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	0.653
RNF121	CGRRF1	ENSP00000354571	ENSP00000216420	Ring finger protein 121; Belongs to the RNF121 family	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	0.602
RNF121	RNF130	ENSP00000354571	ENSP00000430237	Ring finger protein 121; Belongs to the RNF121 family	E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase; Ring finger proteins	0.609
RNF121	RNF145	ENSP00000354571	ENSP00000430955	Ring finger protein 121; Belongs to the RNF121 family	Ring finger protein 145	0.546
RNF121	RNF170	ENSP00000354571	ENSP00000445725	Ring finger protein 121; Belongs to the RNF121 family	E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells; Ring finger proteins	0.644
RNF121	RNF180	ENSP00000354571	ENSP00000373752	Ring finger protein 121; Belongs to the RNF121 family	E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2; Ring finger proteins	0.599
RNF121	RNF185	ENSP00000354571	ENSP00000320508	Ring finger protein 121; Belongs to the RNF121 family	E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating ’Lys-63’-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...]	0.755
RNF121	RNFT1	ENSP00000354571	ENSP00000304670	Ring finger protein 121; Belongs to the RNF121 family	E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis; Ring finger proteins	0.627
RNF130	CGRRF1	ENSP00000430237	ENSP00000216420	E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase; Ring finger proteins	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	0.580

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