PVALB protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PVALB

Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing (110 aa)

Predicted Functional Partners:

CALB1

0.945

CALB2

0.944

SST

0.923

GAD1

0.901

CCK

0.870

GAD2

0.865

NPY

0.850

SDF4

0.831

GRIN1

0.815

RBFOX3

0.810

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALB1	CCK	ENSP00000265431	ENSP00000379472	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Endogenous ligands	0.725
CALB1	GAD1	ENSP00000265431	ENSP00000350928	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	0.802
CALB1	GAD2	ENSP00000265431	ENSP00000365437	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Glutamate decarboxylase 2; Catalyzes the production of GABA	0.762
CALB1	GRIN1	ENSP00000265431	ENSP00000360608	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily	0.644
CALB1	NPY	ENSP00000265431	ENSP00000384364	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family	0.758
CALB1	PVALB	ENSP00000265431	ENSP00000216200	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	0.945
CALB1	RBFOX3	ENSP00000265431	ENSP00000463653	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD); RNA binding motif containing	0.781
CALB1	SDF4	ENSP00000265431	ENSP00000353094	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.836
CALB1	SST	ENSP00000265431	ENSP00000287641	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands	0.770
CALB2	CCK	ENSP00000307508	ENSP00000379472	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Endogenous ligands	0.769
CALB2	GAD1	ENSP00000307508	ENSP00000350928	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	0.827
CALB2	GAD2	ENSP00000307508	ENSP00000365437	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Glutamate decarboxylase 2; Catalyzes the production of GABA	0.766
CALB2	GRIN1	ENSP00000307508	ENSP00000360608	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily	0.635
CALB2	NPY	ENSP00000307508	ENSP00000384364	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family	0.790
CALB2	PVALB	ENSP00000307508	ENSP00000216200	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	0.944
CALB2	RBFOX3	ENSP00000307508	ENSP00000463653	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD); RNA binding motif containing	0.759
CALB2	SDF4	ENSP00000307508	ENSP00000353094	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.740
CALB2	SST	ENSP00000307508	ENSP00000287641	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands	0.857
CCK	CALB1	ENSP00000379472	ENSP00000265431	Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Endogenous ligands	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	0.725
CCK	CALB2	ENSP00000379472	ENSP00000307508	Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Endogenous ligands	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	0.769

page 1 of 5

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2020

Credits

Access

Info

About