| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP1B1 | EWSR1 | ENSP00000350199 | ENSP00000400142 | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | 0.532 |
| AP1B1 | GAS2L1 | ENSP00000350199 | ENSP00000481012 | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments | 0.762 |
| AP1B1 | GAS2L2 | ENSP00000350199 | ENSP00000474529 | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | GAS2-like protein 2; Seems to be involved in the cross-linking of microtubules and microfilaments | 0.400 |
| AP1B1 | RASL10A | ENSP00000350199 | ENSP00000216101 | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family | 0.838 |
| AP1B1 | RFPL1 | ENSP00000350199 | ENSP00000346342 | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | Ret finger protein like 1; Ring finger proteins | 0.430 |
| EWSR1 | AP1B1 | ENSP00000400142 | ENSP00000350199 | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.532 |
| EWSR1 | GAS2L1 | ENSP00000400142 | ENSP00000481012 | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments | 0.673 |
| EWSR1 | RASL10A | ENSP00000400142 | ENSP00000216101 | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family | 0.711 |
| GAS2 | RASL10A | ENSP00000401145 | ENSP00000216101 | Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity) | Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family | 0.757 |
| GAS2 | SPA17 | ENSP00000401145 | ENSP00000432305 | Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity) | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) | 0.711 |
| GAS2L1 | AP1B1 | ENSP00000481012 | ENSP00000350199 | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.762 |
| GAS2L1 | EWSR1 | ENSP00000481012 | ENSP00000400142 | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | 0.673 |
| GAS2L1 | RASL10A | ENSP00000481012 | ENSP00000216101 | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments | Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family | 0.905 |
| GAS2L1 | RFPL1 | ENSP00000481012 | ENSP00000346342 | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments | Ret finger protein like 1; Ring finger proteins | 0.550 |
| GAS2L1 | SPA17 | ENSP00000481012 | ENSP00000432305 | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) | 0.712 |
| GAS2L2 | AP1B1 | ENSP00000474529 | ENSP00000350199 | GAS2-like protein 2; Seems to be involved in the cross-linking of microtubules and microfilaments | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.400 |
| GAS2L2 | RASL10A | ENSP00000474529 | ENSP00000216101 | GAS2-like protein 2; Seems to be involved in the cross-linking of microtubules and microfilaments | Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family | 0.808 |
| GAS2L2 | SPA17 | ENSP00000474529 | ENSP00000432305 | GAS2-like protein 2; Seems to be involved in the cross-linking of microtubules and microfilaments | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) | 0.754 |
| RAP1B | RAP1GDS1 | ENSP00000250559 | ENSP00000340454 | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function; Belongs to the small GTPase superfamily. Ras family | Rap1 GTPase-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein; Armadillo repeat containing | 0.604 |
| RAP1B | RASL10A | ENSP00000250559 | ENSP00000216101 | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function; Belongs to the small GTPase superfamily. Ras family | Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family | 0.871 |
