| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADORA2B | ANKRD54 | ENSP00000304501 | ENSP00000215941 | Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | 0.649 |
| ADORA2B | GPSM1 | ENSP00000304501 | ENSP00000392828 | Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction; Belongs to the GPSM family | 0.635 |
| ANKRD54 | ADORA2B | ENSP00000215941 | ENSP00000304501 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.649 |
| ANKRD54 | GHITM | ENSP00000215941 | ENSP00000361207 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor motif containing | 0.527 |
| ANKRD54 | GNPAT | ENSP00000215941 | ENSP00000355607 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Glyceronephosphate O-acyltransferase | 0.660 |
| ANKRD54 | GPSM1 | ENSP00000215941 | ENSP00000392828 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction; Belongs to the GPSM family | 0.722 |
| ANKRD54 | LIAS | ENSP00000215941 | ENSP00000261434 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | 0.793 |
| ANKRD54 | LYN | ENSP00000215941 | ENSP00000428924 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B- [...] | 0.594 |
| ANKRD54 | NOTUM | ENSP00000215941 | ENSP00000387310 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors | 0.544 |
| ANKRD54 | PLEKHM3 | ENSP00000215941 | ENSP00000417003 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Pleckstrin homology domain containing M3 | 0.625 |
| ANKRD54 | SH3YL1 | ENSP00000215941 | ENSP00000348471 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | SH3 domain-containing YSC84-like protein 1; SH3 and SYLF domain containing 1 | 0.550 |
| ANKRD54 | TULP3 | ENSP00000215941 | ENSP00000380321 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | Tubby-related protein 3; Negative regulator of the Shh signaling transduction pathway- recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT- A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis; Belongs to the TUB family | 0.544 |
| GHITM | ANKRD54 | ENSP00000361207 | ENSP00000215941 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor motif containing | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | 0.527 |
| GNPAT | ANKRD54 | ENSP00000355607 | ENSP00000215941 | Glyceronephosphate O-acyltransferase | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | 0.660 |
| GPSM1 | ADORA2B | ENSP00000392828 | ENSP00000304501 | G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction; Belongs to the GPSM family | Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.635 |
| GPSM1 | ANKRD54 | ENSP00000392828 | ENSP00000215941 | G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction; Belongs to the GPSM family | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | 0.722 |
| LIAS | ANKRD54 | ENSP00000261434 | ENSP00000215941 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | 0.793 |
| LIAS | PLEKHM3 | ENSP00000261434 | ENSP00000417003 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | Pleckstrin homology domain containing M3 | 0.547 |
| LYN | ANKRD54 | ENSP00000428924 | ENSP00000215941 | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B- [...] | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | 0.594 |
| NOTUM | ANKRD54 | ENSP00000387310 | ENSP00000215941 | Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain containing | 0.544 |
