• Version:
  • 11.0 [archived version]
STRINGSTRING
IFITM5 IFITM5 FLAD1 FLAD1 SNN SNN HMCN2 HMCN2 SLC39A14 SLC39A14 SRRD SRRD PON3 PON3 HDGFRP3 HDGFRP3 STT3B STT3B HNRNPM HNRNPM
"SRRD" - SRR1-like protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
SRRDSRR1-like protein; May be involved in a circadian clock input pathway (339 aa)    
Predicted Functional Partners:
HMCN2
Hemicentin-2; Immunoglobulin like domain containing; Fibulins (5059 aa)
           
  0.661
HDGFRP3
Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation (203 aa)
           
  0.638
PON3
Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family (354 aa)
           
  0.541
SNN
Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation (88 aa)
           
  0.501
FLAD1
FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily (587 aa)
           
  0.450
STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of [...] (826 aa)
           
  0.441
HNRNPM
Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (730 aa)
           
  0.410
IFITM5
Interferon-induced transmembrane protein 5; Required for normal bone mineralization; Belongs to the CD225/Dispanin family (132 aa)
           
  0.401
SLC39A14
Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron; Belongs to the ZIP transporter (TC 2.A.5) family (492 aa)
           
  0.401
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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