node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FLAD1 | SRRD | ENSP00000292180 | ENSP00000215917 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily | SRR1-like protein; May be involved in a circadian clock input pathway | 0.450 |
HDGFRP3 | HMCN2 | ENSP00000299633 | ENSP00000485357 | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | 0.634 |
HDGFRP3 | PON3 | ENSP00000299633 | ENSP00000265627 | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family | 0.514 |
HDGFRP3 | SNN | ENSP00000299633 | ENSP00000329287 | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.475 |
HDGFRP3 | SRRD | ENSP00000299633 | ENSP00000215917 | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation | SRR1-like protein; May be involved in a circadian clock input pathway | 0.638 |
HMCN2 | HDGFRP3 | ENSP00000485357 | ENSP00000299633 | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation | 0.634 |
HMCN2 | IFITM5 | ENSP00000485357 | ENSP00000372059 | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | Interferon-induced transmembrane protein 5; Required for normal bone mineralization; Belongs to the CD225/Dispanin family | 0.413 |
HMCN2 | PON3 | ENSP00000485357 | ENSP00000265627 | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family | 0.644 |
HMCN2 | SNN | ENSP00000485357 | ENSP00000329287 | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.564 |
HMCN2 | SRRD | ENSP00000485357 | ENSP00000215917 | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | SRR1-like protein; May be involved in a circadian clock input pathway | 0.661 |
HNRNPM | SRRD | ENSP00000325376 | ENSP00000215917 | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | SRR1-like protein; May be involved in a circadian clock input pathway | 0.410 |
IFITM5 | HMCN2 | ENSP00000372059 | ENSP00000485357 | Interferon-induced transmembrane protein 5; Required for normal bone mineralization; Belongs to the CD225/Dispanin family | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | 0.413 |
IFITM5 | SRRD | ENSP00000372059 | ENSP00000215917 | Interferon-induced transmembrane protein 5; Required for normal bone mineralization; Belongs to the CD225/Dispanin family | SRR1-like protein; May be involved in a circadian clock input pathway | 0.401 |
PON3 | HDGFRP3 | ENSP00000265627 | ENSP00000299633 | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation | 0.514 |
PON3 | HMCN2 | ENSP00000265627 | ENSP00000485357 | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | 0.644 |
PON3 | SNN | ENSP00000265627 | ENSP00000329287 | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.477 |
PON3 | SRRD | ENSP00000265627 | ENSP00000215917 | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family | SRR1-like protein; May be involved in a circadian clock input pathway | 0.541 |
SLC39A14 | SRRD | ENSP00000352779 | ENSP00000215917 | Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron; Belongs to the ZIP transporter (TC 2.A.5) family | SRR1-like protein; May be involved in a circadian clock input pathway | 0.401 |
SNN | HDGFRP3 | ENSP00000329287 | ENSP00000299633 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation | 0.475 |
SNN | HMCN2 | ENSP00000329287 | ENSP00000485357 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | 0.564 |