node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX5AP | LGALS2 | ENSP00000479870 | ENSP00000215886 | Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes; Belongs to the MAPEG family | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.443 |
GCSAM | LGALS2 | ENSP00000419485 | ENSP00000215886 | Germinal center-associated signaling and motility protein; Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.592 |
IGSF23 | LGALS2 | ENSP00000385592 | ENSP00000215886 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.461 |
LGALS2 | ALOX5AP | ENSP00000215886 | ENSP00000479870 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes; Belongs to the MAPEG family | 0.443 |
LGALS2 | GCSAM | ENSP00000215886 | ENSP00000419485 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Germinal center-associated signaling and motility protein; Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation | 0.592 |
LGALS2 | IGSF23 | ENSP00000215886 | ENSP00000385592 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | 0.461 |
LGALS2 | LTA | ENSP00000215886 | ENSP00000403495 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo; Tumor necrosis factor superfamily | 0.674 |
LGALS2 | NAT8 | ENSP00000215886 | ENSP00000272425 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | N-acetyltransferase 8; Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various protei [...] | 0.409 |
LGALS2 | NR1H4 | ENSP00000215886 | ENSP00000447149 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Bile acid receptor; Isoform 4- Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA; Belongs to the nuclear hormone receptor family. NR1 subfamily | 0.444 |
LGALS2 | NXPE1 | ENSP00000215886 | ENSP00000251921 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family | 0.428 |
LGALS2 | PAICS | ENSP00000215886 | ENSP00000382595 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Multifunctional protein ADE2; Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily | 0.505 |
LGALS2 | PSMA6 | ENSP00000215886 | ENSP00000261479 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Proteasome subunit alpha type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.424 |
LGALS2 | SDPR | ENSP00000215886 | ENSP00000305675 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | Caveolae-associated protein 2; Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity) | 0.567 |
LTA | LGALS2 | ENSP00000403495 | ENSP00000215886 | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo; Tumor necrosis factor superfamily | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.674 |
LTA | PSMA6 | ENSP00000403495 | ENSP00000261479 | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo; Tumor necrosis factor superfamily | Proteasome subunit alpha type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.902 |
NAT8 | LGALS2 | ENSP00000272425 | ENSP00000215886 | N-acetyltransferase 8; Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various protei [...] | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.409 |
NR1H4 | LGALS2 | ENSP00000447149 | ENSP00000215886 | Bile acid receptor; Isoform 4- Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA; Belongs to the nuclear hormone receptor family. NR1 subfamily | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.444 |
NXPE1 | LGALS2 | ENSP00000251921 | ENSP00000215886 | NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.428 |
PAICS | LGALS2 | ENSP00000382595 | ENSP00000215886 | Multifunctional protein ADE2; Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.505 |
PSMA6 | LGALS2 | ENSP00000261479 | ENSP00000215886 | Proteasome subunit alpha type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins | 0.424 |