OCEL1 protein (human) - STRING database

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OCEL1

occludin/ELL domain containing 1; Belongs to the ELL/occludin family (264 aa)

Predicted Functional Partners:

FAM217B

0.734

FICD

0.656

TMEM205

0.650

METTL7B

0.597

ABHD8

0.575

RAB2B

0.550

PPP1R3D

0.548

MYO9B

0.528

RAB13

0.501

IDI2

0.498

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD8	FAM217B	ENSP00000247706	ENSP00000351040	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family	0.571
ABHD8	MYO9B	ENSP00000247706	ENSP00000471457	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereb [...]	0.511
ABHD8	OCEL1	ENSP00000247706	ENSP00000215061	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	0.575
FAM217B	ABHD8	ENSP00000351040	ENSP00000247706	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	0.571
FAM217B	MYO9B	ENSP00000351040	ENSP00000471457	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family	Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereb [...]	0.514
FAM217B	OCEL1	ENSP00000351040	ENSP00000215061	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	0.734
FAM217B	PPP1R3D	ENSP00000351040	ENSP00000360035	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family	Protein phosphatase 1 regulatory subunit 3D; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis; Protein phosphatase 1 regulatory subunits	0.769
FICD	IDI2	ENSP00000446479	ENSP00000277517	Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified	Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	0.456
FICD	OCEL1	ENSP00000446479	ENSP00000215061	Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	0.656
FICD	RAB2B	ENSP00000446479	ENSP00000380869	Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified	Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases	0.452
IDI2	FICD	ENSP00000277517	ENSP00000446479	Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified	0.456
IDI2	OCEL1	ENSP00000277517	ENSP00000215061	Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	0.498
METTL7B	OCEL1	ENSP00000377796	ENSP00000215061	Methyltransferase-like protein 7B; Probable methyltransferase	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	0.597
METTL7B	TMEM205	ENSP00000377796	ENSP00000346954	Methyltransferase-like protein 7B; Probable methyltransferase	Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin	0.505
MYO9B	ABHD8	ENSP00000471457	ENSP00000247706	Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereb [...]	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	0.511
MYO9B	FAM217B	ENSP00000471457	ENSP00000351040	Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereb [...]	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family	0.514
MYO9B	OCEL1	ENSP00000471457	ENSP00000215061	Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereb [...]	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	0.528
OCEL1	ABHD8	ENSP00000215061	ENSP00000247706	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	0.575
OCEL1	FAM217B	ENSP00000215061	ENSP00000351040	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family	0.734
OCEL1	FICD	ENSP00000215061	ENSP00000446479	occludin/ELL domain containing 1; Belongs to the ELL/occludin family	Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5’-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified	0.656

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