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  • 11.0 [archived version]
STRINGSTRING
HMGN4 HMGN4 POM121L2 POM121L2 MEX3A MEX3A PRSS16 PRSS16 ARMC10 ARMC10 ZNF184 ZNF184 TRIM28 TRIM28 RRP8 RRP8 SF3B5 SF3B5 PPP1R18 PPP1R18 CAP2 CAP2
"ZNF184" - Zinc finger protein 184 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF184Zinc finger protein 184; May be involved in transcriptional regulation; Zinc fingers C2H2-type (751 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.904
POM121L2
POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family (1035 aa)
           
  0.578
PPP1R18
Phostensin; Isoform 1- May target protein phosphatase 1 to F-actin cytoskeleton (613 aa)
           
  0.545
RRP8
Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
       
      0.542
SF3B5
Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (86 aa)
       
 
  0.533
PRSS16
Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family (514 aa)
           
  0.532
ARMC10
Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53; Armadillo repeat containing (343 aa)
           
  0.514
MEX3A
RNA-binding protein MEX3A; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins (520 aa)
     
   
  0.510
CAP2
Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family (477 aa)
     
   
  0.466
HMGN4
High mobility group nucleosomal binding domain 4; Belongs to the HMGN family (90 aa)
           
  0.463
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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