| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAAS | GLE1 | ENSP00000209873 | ENSP00000308622 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | 0.969 |
| AAAS | NDC1 | ENSP00000209873 | ENSP00000360483 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane | 0.957 |
| AAAS | NUP107 | ENSP00000209873 | ENSP00000229179 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC; Belongs to the nucleoporin Nup84/Nup107 family | 0.987 |
| AAAS | NUP133 | ENSP00000209873 | ENSP00000261396 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport; Belongs to the nucleoporin Nup133 family | 0.965 |
| AAAS | NUP153 | ENSP00000209873 | ENSP00000444029 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.971 |
| AAAS | NUP155 | ENSP00000209873 | ENSP00000231498 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport | 0.973 |
| AAAS | NUP37 | ENSP00000209873 | ENSP00000448054 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin Nup37; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation; Nucleoporins | 0.975 |
| AAAS | NUP43 | ENSP00000209873 | ENSP00000342262 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nucleoporin Nup43; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation; Nucleoporins | 0.981 |
| AAAS | NUP62 | ENSP00000209873 | ENSP00000471191 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown; Nucleoporins | 0.967 |
| AAAS | UBE2I | ENSP00000209873 | ENSP00000348056 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’; Belongs to the ubiquitin-conjugating enzyme family | 0.957 |
| GLE1 | AAAS | ENSP00000308622 | ENSP00000209873 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | 0.969 |
| GLE1 | NDC1 | ENSP00000308622 | ENSP00000360483 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane | 0.917 |
| GLE1 | NUP107 | ENSP00000308622 | ENSP00000229179 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC; Belongs to the nucleoporin Nup84/Nup107 family | 0.990 |
| GLE1 | NUP133 | ENSP00000308622 | ENSP00000261396 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport; Belongs to the nucleoporin Nup133 family | 0.974 |
| GLE1 | NUP153 | ENSP00000308622 | ENSP00000444029 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.988 |
| GLE1 | NUP155 | ENSP00000308622 | ENSP00000231498 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport | 0.993 |
| GLE1 | NUP37 | ENSP00000308622 | ENSP00000448054 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nucleoporin Nup37; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation; Nucleoporins | 0.945 |
| GLE1 | NUP43 | ENSP00000308622 | ENSP00000342262 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nucleoporin Nup43; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation; Nucleoporins | 0.959 |
| GLE1 | NUP62 | ENSP00000308622 | ENSP00000471191 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown; Nucleoporins | 0.969 |
| NDC1 | AAAS | ENSP00000360483 | ENSP00000209873 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins | 0.957 |
