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  • 11.0 [archived version]
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MAML3 MAML3 WARS2 WARS2 HOXA5 HOXA5 RPP14 RPP14 PRRX2 PRRX2 TBX15 TBX15 SHOX2 SHOX2 WNT9B WNT9B SETD2 SETD2 PRRX1 PRRX1 GPC4 GPC4
"TBX15" - T-box transcription factor TBX15 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TBX15T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity); T-boxes (496 aa)    
Predicted Functional Partners:
SHOX2
Short stature homeobox protein 2; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation; PRD class homeoboxes and pseudogenes (355 aa)
     
 
  0.664
PRRX1
Paired mesoderm homeobox protein 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity); Belongs to the paired homeobox family (245 aa)
     
 
  0.645
PRRX2
Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family (253 aa)
     
 
  0.624
RPP14
Ribonuclease P protein subunit p14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (124 aa)
           
  0.620
WNT9B
Protein Wnt-9b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity) (357 aa)
     
 
  0.619
WARS2
Tryptophan--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis (360 aa)
           
  0.605
GPC4
Glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity); Belongs to the glypican family (556 aa)
       
 
  0.595
MAML3
Mastermind-like protein 3; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1; Belongs to the mastermind family (1138 aa)
           
  0.594
HOXA5
Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’; HOXL subclass homeoboxes (270 aa)
       
 
  0.569
SETD2
Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates ’Lys-36’ of histone H3 (H3K36me3) using dimethylated ’Lys-36’ (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recr [...] (2564 aa)
       
 
  0.567
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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