TGM1 protein (human) - STRING database

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TGM1

Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family (817 aa)

Predicted Functional Partners:

IVL

0.979

LOR

0.979

FLG

0.971

CSTA

0.954

SPRR1B

0.952

CDSN

0.951

SPRR1A

0.950

EVPL

0.947

DSG1

0.946

PPL

0.942

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDSN	CSTA	ENSP00000365465	ENSP00000264474	Corneodesmosin; Important for the epidermal barrier integrity	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	0.935
CDSN	DSG1	ENSP00000365465	ENSP00000257192	Corneodesmosin; Important for the epidermal barrier integrity	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	0.738
CDSN	EVPL	ENSP00000365465	ENSP00000301607	Corneodesmosin; Important for the epidermal barrier integrity	Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins	0.948
CDSN	FLG	ENSP00000365465	ENSP00000357789	Corneodesmosin; Important for the epidermal barrier integrity	Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing	0.676
CDSN	IVL	ENSP00000365465	ENSP00000357753	Corneodesmosin; Important for the epidermal barrier integrity	Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family	0.956
CDSN	LOR	ENSP00000365465	ENSP00000357731	Corneodesmosin; Important for the epidermal barrier integrity	Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family	0.965
CDSN	PPL	ENSP00000365465	ENSP00000340510	Corneodesmosin; Important for the epidermal barrier integrity	Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family	0.940
CDSN	SPRR1A	ENSP00000365465	ENSP00000357751	Corneodesmosin; Important for the epidermal barrier integrity	Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins	0.930
CDSN	SPRR1B	ENSP00000365465	ENSP00000306461	Corneodesmosin; Important for the epidermal barrier integrity	Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family	0.938
CDSN	TGM1	ENSP00000365465	ENSP00000206765	Corneodesmosin; Important for the epidermal barrier integrity	Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family	0.951
CSTA	CDSN	ENSP00000264474	ENSP00000365465	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Corneodesmosin; Important for the epidermal barrier integrity	0.935
CSTA	DSG1	ENSP00000264474	ENSP00000257192	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	0.922
CSTA	EVPL	ENSP00000264474	ENSP00000301607	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins	0.934
CSTA	FLG	ENSP00000264474	ENSP00000357789	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing	0.937
CSTA	IVL	ENSP00000264474	ENSP00000357753	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family	0.960
CSTA	LOR	ENSP00000264474	ENSP00000357731	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family	0.955
CSTA	PPL	ENSP00000264474	ENSP00000340510	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family	0.918
CSTA	SPRR1A	ENSP00000264474	ENSP00000357751	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins	0.919
CSTA	SPRR1B	ENSP00000264474	ENSP00000306461	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family	0.911
CSTA	TGM1	ENSP00000264474	ENSP00000206765	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family	Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family	0.954

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