• Version:
  • 11.0 [archived version]
STRINGSTRING
IAH1 IAH1 TTC38 TTC38 GAS2L3 GAS2L3 G2E3 G2E3 PRR11 PRR11 BTBD3 BTBD3 KIF11 KIF11 CKAP2L CKAP2L LRRC17 LRRC17 ARHGEF39 ARHGEF39 BORA BORA
"G2E3" - G2/M phase-specific E3 ubiquitin-protein ligase in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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G2E3G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death; PHD finger proteins (706 aa)    
Predicted Functional Partners:
IAH1
Isoamyl acetate-hydrolyzing esterase 1 homolog; Probable lipase (248 aa)
           
  0.649
CKAP2L
Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells (745 aa)
     
   
  0.648
ARHGEF39
Rho guanine nucleotide exchange factor 39; Promotes cell proliferation (335 aa)
     
   
  0.641
LRRC17
Leucine-rich repeat-containing protein 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity) (441 aa)
       
 
  0.634
TTC38
Tetratricopeptide repeat domain containing; Belongs to the TTC38 family (469 aa)
           
  0.611
KIF11
Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily (1056 aa)
     
   
  0.598
GAS2L3
GAS2-like protein 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network; Belongs to the GAS2 family (694 aa)
     
 
  0.592
PRR11
Proline-rich protein 11; Plays a critical role in cell cycle progression (360 aa)
     
   
  0.573
BORA
Protein aurora borealis; Required for the activation of AURKA at the onset of mitosis (634 aa)
     
   
  0.569
BTBD3
BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing (522 aa)
           
  0.559
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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