| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP6V0C | CMTM6 | ENSP00000329757 | ENSP00000205636 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | 0.939 |
| ATP6V0C | DDOST | ENSP00000329757 | ENSP00000399457 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation; Glutamine amidotransferase like class 1 domain containing | 0.905 |
| ATP6V0C | GLIPR1 | ENSP00000329757 | ENSP00000266659 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1 | 0.902 |
| ATP6V0C | LAMP2 | ENSP00000329757 | ENSP00000408411 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Lysosome-associated membrane glycoprotein 2; Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation. Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels o [...] | 0.924 |
| ATP6V0C | LAMTOR2 | ENSP00000329757 | ENSP00000357288 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP ki [...] | 0.929 |
| ATP6V0C | LAMTOR3 | ENSP00000329757 | ENSP00000424183 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP ki [...] | 0.903 |
| ATP6V0C | TMEM30A | ENSP00000329757 | ENSP00000230461 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2-TMEM30A flippase complex. [...] | 0.901 |
| ATP6V0C | VAMP8 | ENSP00000329757 | ENSP00000263864 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.916 |
| CMTM6 | ATP6V0C | ENSP00000205636 | ENSP00000329757 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.939 |
| CMTM6 | CMTM7 | ENSP00000205636 | ENSP00000335605 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family | 0.908 |
| CMTM6 | CMTM8 | ENSP00000205636 | ENSP00000307741 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family | 0.928 |
| CMTM6 | DDOST | ENSP00000205636 | ENSP00000399457 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation; Glutamine amidotransferase like class 1 domain containing | 0.909 |
| CMTM6 | GLIPR1 | ENSP00000205636 | ENSP00000266659 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1 | 0.924 |
| CMTM6 | LAMP2 | ENSP00000205636 | ENSP00000408411 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | Lysosome-associated membrane glycoprotein 2; Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation. Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels o [...] | 0.911 |
| CMTM6 | LAMTOR2 | ENSP00000205636 | ENSP00000357288 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP ki [...] | 0.909 |
| CMTM6 | LAMTOR3 | ENSP00000205636 | ENSP00000424183 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP ki [...] | 0.908 |
| CMTM6 | TMEM30A | ENSP00000205636 | ENSP00000230461 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2-TMEM30A flippase complex. [...] | 0.908 |
| CMTM6 | VAMP8 | ENSP00000205636 | ENSP00000263864 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.909 |
| CMTM7 | CMTM6 | ENSP00000335605 | ENSP00000205636 | CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | 0.908 |
| CMTM7 | CMTM8 | ENSP00000335605 | ENSP00000307741 | CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family | CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family | 0.958 |
