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  • 11.0 [archived version]
STRINGSTRING
TSHB TSHB TOX4 TOX4 CHD8 CHD8 HECW1 HECW1 PUS7 PUS7 SALL2 SALL2 STARD3NL STARD3NL EPDR1 EPDR1 CCDC71 CCDC71 AMZ1 AMZ1 RAD9A RAD9A
"EPDR1" - Mammalian ependymin-related protein 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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EPDR1Mammalian ependymin-related protein 1; Ependymin related 1 (224 aa)    
Predicted Functional Partners:
STARD3NL
STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes- localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB; Belongs to the STARD3 family (234 aa)
      
   
  0.806
HECW1
E3 ubiquitin-protein ligase HECW1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS; C2 domain containing (1606 aa)
      
   
  0.696
TOX4
TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (621 aa)
            
  0.643
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsiv [...] (2581 aa)
            
  0.643
SALL2
Sal-like protein 2; Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure; Zinc fingers C2H2-type (1007 aa)
      
   
  0.586
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands (138 aa)
        
      0.532
CCDC71
Coiled-coil domain containing 71 (467 aa)
            
  0.503
PUS7
Pseudouridylate synthase 7 (661 aa)
            
  0.471
RAD9A
Cell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN [...] (391 aa)
            
  0.464
AMZ1
Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2; Belongs to the peptidase M54 family (498 aa)
            
  0.449
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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