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STRINGSTRING
RNF39 RNF39 PRRT1 PRRT1 NWD1 NWD1 LY6G5C LY6G5C MAGEE2 MAGEE2 PUS7L PUS7L ZNF416 ZNF416 ARID3B ARID3B TRIM28 TRIM28 TRIM37 TRIM37 ZNF211 ZNF211
"ZNF416" - Zinc finger protein 416 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
ZNF416Zinc finger protein 416; May be involved in transcriptional regulation; Zinc fingers C2H2-type (594 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
  0.914
ZNF211
Zinc finger protein 211; Zinc fingers C2H2-type (629 aa)
      
   
0.830
TRIM37
E3 ubiquitin-protein ligase TRIM37; E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of ’Lys-119’ of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression- associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Has anti-HIV activity; Belongs to the TRIM/RBCC family (964 aa)
      
      0.776
PUS7L
Pseudouridylate synthase 7 like (701 aa)
            
  0.631
NWD1
NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing (1432 aa)
        
 
  0.602
MAGEE2
Melanoma-associated antigen E2; MAGE family member E2 (523 aa)
            
  0.580
LY6G5C
Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing (150 aa)
            
  0.511
RNF39
RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance; Ring finger proteins (420 aa)
      
 
  0.494
PRRT1
Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family (306 aa)
            
  0.457
ARID3B
AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A; AT-rich interaction domain containing (560 aa)
        
 
  0.437
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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