| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAT1 | ACAT2 | ENSP00000265838 | ENSP00000356015 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 0.947 |
| ACAT1 | BDH1 | ENSP00000265838 | ENSP00000376184 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.699 |
| ACAT1 | BDH2 | ENSP00000265838 | ENSP00000296424 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity); Short chain dehydrogenase/reductase superfamily | 0.447 |
| ACAT1 | EHHADH | ENSP00000265838 | ENSP00000231887 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family | 0.967 |
| ACAT1 | HADH | ENSP00000265838 | ENSP00000474560 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family | 0.991 |
| ACAT1 | HMGCL | ENSP00000265838 | ENSP00000363614 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism | 0.956 |
| ACAT1 | HMGCLL1 | ENSP00000265838 | ENSP00000381654 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues | 0.942 |
| ACAT1 | HMGCS1 | ENSP00000265838 | ENSP00000322706 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.984 |
| ACAT1 | HMGCS2 | ENSP00000265838 | ENSP00000358414 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.982 |
| ACAT1 | OXCT1 | ENSP00000265838 | ENSP00000196371 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Succinyl-CoA-3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate; Belongs to the 3-oxoacid CoA-transferase family | 0.978 |
| ACAT2 | ACAT1 | ENSP00000356015 | ENSP00000265838 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.947 |
| ACAT2 | BDH2 | ENSP00000356015 | ENSP00000296424 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity); Short chain dehydrogenase/reductase superfamily | 0.409 |
| ACAT2 | EHHADH | ENSP00000356015 | ENSP00000231887 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family | 0.971 |
| ACAT2 | HADH | ENSP00000356015 | ENSP00000474560 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family | 0.991 |
| ACAT2 | HMGCL | ENSP00000356015 | ENSP00000363614 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism | 0.954 |
| ACAT2 | HMGCLL1 | ENSP00000356015 | ENSP00000381654 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues | 0.951 |
| ACAT2 | HMGCS1 | ENSP00000356015 | ENSP00000322706 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.989 |
| ACAT2 | HMGCS2 | ENSP00000356015 | ENSP00000358414 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.980 |
| ACAT2 | OXCT1 | ENSP00000356015 | ENSP00000196371 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Succinyl-CoA-3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate; Belongs to the 3-oxoacid CoA-transferase family | 0.961 |
| BDH1 | ACAT1 | ENSP00000376184 | ENSP00000265838 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.699 |
