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  • 11.0 [archived version]
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SUPT5H SUPT5H ZNF76 ZNF76 MORC1 MORC1 FANCE FANCE ANKS1A ANKS1A UHRF1BP1 UHRF1BP1 C6orf106 C6orf106 WDFY4 WDFY4 SNRPC SNRPC TNIP1 TNIP1 PHRF1 PHRF1
"UHRF1BP1" - UHRF1-binding protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
UHRF1BP1UHRF1-binding protein 1; May act as a negative regulator of cell growth (1440 aa)    
Predicted Functional Partners:
SNRPC
U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] (159 aa)
           
  0.717
ANKS1A
Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing (1134 aa)
     
   
  0.687
SUPT5H
Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] (1087 aa)
           
  0.628
ZNF76
Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type (570 aa)
           
  0.626
WDFY4
WD repeat- and FYVE domain-containing protein 4; Armadillo-like helical domain containing (3184 aa)
     
   
  0.612
MORC1
MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type (984 aa)
           
  0.611
C6orf106
Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 (298 aa)
           
  0.585
FANCE
Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2 (536 aa)
           
  0.569
TNIP1
TNFAIP3-interacting protein 1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this [...] (636 aa)
           
  0.560
PHRF1
PHD and RING finger domain-containing protein 1; Protein phosphatase 1 regulatory subunits; PHD finger proteins (1649 aa)
           
  0.556
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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