node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKS1A | C6orf106 | ENSP00000353518 | ENSP00000363135 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 0.519 |
ANKS1A | FANCE | ENSP00000353518 | ENSP00000229769 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2 | 0.567 |
ANKS1A | SNRPC | ENSP00000353518 | ENSP00000244520 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | 0.638 |
ANKS1A | UHRF1BP1 | ENSP00000353518 | ENSP00000192788 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | UHRF1-binding protein 1; May act as a negative regulator of cell growth | 0.687 |
ANKS1A | ZNF76 | ENSP00000353518 | ENSP00000363064 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.576 |
C6orf106 | ANKS1A | ENSP00000363135 | ENSP00000353518 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | 0.519 |
C6orf106 | SNRPC | ENSP00000363135 | ENSP00000244520 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | 0.535 |
C6orf106 | UHRF1BP1 | ENSP00000363135 | ENSP00000192788 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | UHRF1-binding protein 1; May act as a negative regulator of cell growth | 0.585 |
FANCE | ANKS1A | ENSP00000229769 | ENSP00000353518 | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | 0.567 |
FANCE | UHRF1BP1 | ENSP00000229769 | ENSP00000192788 | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2 | UHRF1-binding protein 1; May act as a negative regulator of cell growth | 0.569 |
FANCE | ZNF76 | ENSP00000229769 | ENSP00000363064 | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.535 |
MORC1 | SUPT5H | ENSP00000232603 | ENSP00000470252 | MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | 0.579 |
MORC1 | UHRF1BP1 | ENSP00000232603 | ENSP00000192788 | MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type | UHRF1-binding protein 1; May act as a negative regulator of cell growth | 0.611 |
PHRF1 | TNIP1 | ENSP00000264555 | ENSP00000317891 | PHD and RING finger domain-containing protein 1; Protein phosphatase 1 regulatory subunits; PHD finger proteins | TNFAIP3-interacting protein 1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this [...] | 0.458 |
PHRF1 | UHRF1BP1 | ENSP00000264555 | ENSP00000192788 | PHD and RING finger domain-containing protein 1; Protein phosphatase 1 regulatory subunits; PHD finger proteins | UHRF1-binding protein 1; May act as a negative regulator of cell growth | 0.556 |
PHRF1 | WDFY4 | ENSP00000264555 | ENSP00000320563 | PHD and RING finger domain-containing protein 1; Protein phosphatase 1 regulatory subunits; PHD finger proteins | WD repeat- and FYVE domain-containing protein 4; Armadillo-like helical domain containing | 0.444 |
SNRPC | ANKS1A | ENSP00000244520 | ENSP00000353518 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | 0.638 |
SNRPC | C6orf106 | ENSP00000244520 | ENSP00000363135 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 0.535 |
SNRPC | UHRF1BP1 | ENSP00000244520 | ENSP00000192788 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | UHRF1-binding protein 1; May act as a negative regulator of cell growth | 0.717 |
SUPT5H | MORC1 | ENSP00000470252 | ENSP00000232603 | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type | 0.579 |