MRPS34 protein (human) - STRING database

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MRPS34

28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation (225 aa)

Predicted Functional Partners:

MRPS26

0.997

MRPS16

0.996

MRPS25

0.996

MRPL44

0.995

MRPL36

0.995

MRPS2

0.995

GADD45GIP1

0.994

MRPL41

0.993

MRPS22

0.992

MRPL11

0.991

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GADD45GIP1	MRPL11	ENSP00000323065	ENSP00000308897	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	0.997
GADD45GIP1	MRPL36	ENSP00000323065	ENSP00000423399	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family	0.988
GADD45GIP1	MRPL41	ENSP00000323065	ENSP00000360498	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins	0.996
GADD45GIP1	MRPL44	ENSP00000323065	ENSP00000258383	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Mitochondrial ribosomal proteins	0.985
GADD45GIP1	MRPS16	ENSP00000323065	ENSP00000362036	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family	0.983
GADD45GIP1	MRPS2	ENSP00000323065	ENSP00000360850	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family	0.988
GADD45GIP1	MRPS22	ENSP00000323065	ENSP00000418008	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	Mitochondrial ribosomal protein S22; Belongs to the mitochondrion-specific ribosomal protein mS22 family	0.982
GADD45GIP1	MRPS25	ENSP00000323065	ENSP00000253686	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	Mitochondrial ribosomal protein S25	0.981
GADD45GIP1	MRPS26	ENSP00000323065	ENSP00000369682	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	Mitochondrial ribosomal protein S26; Belongs to the mitochondrion-specific ribosomal protein mS26 family	0.987
GADD45GIP1	MRPS34	ENSP00000323065	ENSP00000177742	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation	0.994
MRPL11	GADD45GIP1	ENSP00000308897	ENSP00000323065	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis	0.997
MRPL11	MRPL36	ENSP00000308897	ENSP00000423399	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family	0.998
MRPL11	MRPL41	ENSP00000308897	ENSP00000360498	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins	0.998
MRPL11	MRPL44	ENSP00000308897	ENSP00000258383	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Mitochondrial ribosomal proteins	0.995
MRPL11	MRPS16	ENSP00000308897	ENSP00000362036	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family	0.999
MRPL11	MRPS2	ENSP00000308897	ENSP00000360850	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family	0.995
MRPL11	MRPS22	ENSP00000308897	ENSP00000418008	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	Mitochondrial ribosomal protein S22; Belongs to the mitochondrion-specific ribosomal protein mS22 family	0.993
MRPL11	MRPS25	ENSP00000308897	ENSP00000253686	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	Mitochondrial ribosomal protein S25	0.984
MRPL11	MRPS26	ENSP00000308897	ENSP00000369682	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	Mitochondrial ribosomal protein S26; Belongs to the mitochondrion-specific ribosomal protein mS26 family	0.986
MRPL11	MRPS34	ENSP00000308897	ENSP00000177742	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation	0.991

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