| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATAD1 | ISOC1 | ENSP00000339017 | ENSP00000173527 | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity); AAA ATPases | Isochorismatase domain containing 1 | 0.573 |
| ATAD1 | MARC2 | ENSP00000339017 | ENSP00000355880 | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity); AAA ATPases | Mitochondrial amidoxime reducing component 2; As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively | 0.699 |
| ATAD1 | PEX3 | ENSP00000339017 | ENSP00000356563 | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity); AAA ATPases | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family | 0.422 |
| DNAJB5 | ISOC1 | ENSP00000404079 | ENSP00000173527 | DnaJ heat shock protein family member B5 | Isochorismatase domain containing 1 | 0.705 |
| DNAJB5 | METTL13 | ENSP00000404079 | ENSP00000354920 | DnaJ heat shock protein family member B5 | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily | 0.602 |
| DNAJB5 | RBBP4 | ENSP00000404079 | ENSP00000362592 | DnaJ heat shock protein family member B5 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.579 |
| ISOC1 | ATAD1 | ENSP00000173527 | ENSP00000339017 | Isochorismatase domain containing 1 | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity); AAA ATPases | 0.573 |
| ISOC1 | DNAJB5 | ENSP00000173527 | ENSP00000404079 | Isochorismatase domain containing 1 | DnaJ heat shock protein family member B5 | 0.705 |
| ISOC1 | KIAA1024L | ENSP00000173527 | ENSP00000454268 | Isochorismatase domain containing 1 | UPF0258 protein KIAA1024-like; KIAA1024 like | 0.630 |
| ISOC1 | MARC2 | ENSP00000173527 | ENSP00000355880 | Isochorismatase domain containing 1 | Mitochondrial amidoxime reducing component 2; As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively | 0.588 |
| ISOC1 | METTL13 | ENSP00000173527 | ENSP00000354920 | Isochorismatase domain containing 1 | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily | 0.662 |
| ISOC1 | PECR | ENSP00000173527 | ENSP00000265322 | Isochorismatase domain containing 1 | Peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity; Short chain dehydrogenase/reductase superfamily | 0.650 |
| ISOC1 | PEX11B | ENSP00000173527 | ENSP00000358312 | Isochorismatase domain containing 1 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family | 0.758 |
| ISOC1 | PEX3 | ENSP00000173527 | ENSP00000356563 | Isochorismatase domain containing 1 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family | 0.697 |
| ISOC1 | PSMC1 | ENSP00000173527 | ENSP00000261303 | Isochorismatase domain containing 1 | 26S proteasome regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 0.699 |
| ISOC1 | RBBP4 | ENSP00000173527 | ENSP00000362592 | Isochorismatase domain containing 1 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.590 |
| KIAA1024L | ISOC1 | ENSP00000454268 | ENSP00000173527 | UPF0258 protein KIAA1024-like; KIAA1024 like | Isochorismatase domain containing 1 | 0.630 |
| MARC2 | ATAD1 | ENSP00000355880 | ENSP00000339017 | Mitochondrial amidoxime reducing component 2; As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity); AAA ATPases | 0.699 |
| MARC2 | ISOC1 | ENSP00000355880 | ENSP00000173527 | Mitochondrial amidoxime reducing component 2; As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively | Isochorismatase domain containing 1 | 0.588 |
| METTL13 | DNAJB5 | ENSP00000354920 | ENSP00000404079 | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily | DnaJ heat shock protein family member B5 | 0.602 |
