FOXJ2 protein (human) - STRING database

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FOXJ2

Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes (574 aa)

Predicted Functional Partners:

GATAD2B

0.594

MXD3

0.553

CDC5L

0.544

C6orf222

0.524

POU3F2

0.522

CDX4

0.508

C4orf17

0.488

TBX4

0.487

FARSA

0.486

AFAP1

0.486

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFAP1	FOXJ2	ENSP00000410689	ENSP00000162391	Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells; Pleckstrin homology domain containing	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.486
C4orf17	FOXJ2	ENSP00000322582	ENSP00000162391	Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.488
C6orf222	FOXJ2	ENSP00000418983	ENSP00000162391	Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.524
CDC5L	FOXJ2	ENSP00000360532	ENSP00000162391	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.544
CDX4	FOXJ2	ENSP00000362613	ENSP00000162391	Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.508
FARSA	FOXJ2	ENSP00000320309	ENSP00000162391	phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.486
FOXJ2	AFAP1	ENSP00000162391	ENSP00000410689	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells; Pleckstrin homology domain containing	0.486
FOXJ2	C4orf17	ENSP00000162391	ENSP00000322582	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17	0.488
FOXJ2	C6orf222	ENSP00000162391	ENSP00000418983	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222	0.524
FOXJ2	CDC5L	ENSP00000162391	ENSP00000360532	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	0.544
FOXJ2	CDX4	ENSP00000162391	ENSP00000362613	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family	0.508
FOXJ2	FARSA	ENSP00000162391	ENSP00000320309	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II	0.486
FOXJ2	GATAD2B	ENSP00000162391	ENSP00000357644	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	Transcriptional repressor p66-beta; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development; GATA zinc finger domain containing	0.594
FOXJ2	MXD3	ENSP00000162391	ENSP00000401867	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	Max dimerization protein 3; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity); Basic helix-loop-helix proteins	0.553
FOXJ2	POU3F2	ENSP00000162391	ENSP00000329170	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...]	0.522
FOXJ2	TBX4	ENSP00000162391	ENSP00000240335	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	T-box transcription factor TBX4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation; T-boxes	0.487
GATAD2B	FOXJ2	ENSP00000357644	ENSP00000162391	Transcriptional repressor p66-beta; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development; GATA zinc finger domain containing	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.594
MXD3	FOXJ2	ENSP00000401867	ENSP00000162391	Max dimerization protein 3; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity); Basic helix-loop-helix proteins	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.553
POU3F2	FOXJ2	ENSP00000329170	ENSP00000162391	POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...]	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.522
TBX4	FOXJ2	ENSP00000240335	ENSP00000162391	T-box transcription factor TBX4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation; T-boxes	Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes	0.487

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