node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALML3 | ISOC2 | ENSP00000315299 | ENSP00000085068 | Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates | Isochorismatase domain containing 2 | 0.723 |
FIZ1 | ISOC2 | ENSP00000221665 | ENSP00000085068 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity); Zinc fingers C2H2-type | Isochorismatase domain containing 2 | 0.578 |
FIZ1 | NAT14 | ENSP00000221665 | ENSP00000205194 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity); Zinc fingers C2H2-type | N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases | 0.456 |
FIZ1 | PPP6R1 | ENSP00000221665 | ENSP00000414202 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity); Zinc fingers C2H2-type | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.400 |
ISOC2 | CALML3 | ENSP00000085068 | ENSP00000315299 | Isochorismatase domain containing 2 | Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates | 0.723 |
ISOC2 | FIZ1 | ENSP00000085068 | ENSP00000221665 | Isochorismatase domain containing 2 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity); Zinc fingers C2H2-type | 0.578 |
ISOC2 | IZUMO3 | ENSP00000085068 | ENSP00000474246 | Isochorismatase domain containing 2 | Izumo sperm-egg fusion protein 3; IZUMO family member 3 | 0.633 |
ISOC2 | NAT14 | ENSP00000085068 | ENSP00000205194 | Isochorismatase domain containing 2 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases | 0.614 |
ISOC2 | PPP6R1 | ENSP00000085068 | ENSP00000414202 | Isochorismatase domain containing 2 | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.744 |
ISOC2 | PRELID1 | ENSP00000085068 | ENSP00000302114 | Isochorismatase domain containing 2 | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1-PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induce [...] | 0.582 |
ISOC2 | RASIP1 | ENSP00000085068 | ENSP00000222145 | Isochorismatase domain containing 2 | Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRA [...] | 0.617 |
ISOC2 | RDH13 | ENSP00000085068 | ENSP00000391121 | Isochorismatase domain containing 2 | Retinol dehydrogenase 13; Does not exhibit retinol dehydrogenase (RDH) activity in vitro; Short chain dehydrogenase/reductase superfamily | 0.599 |
ISOC2 | TMEM86B | ENSP00000085068 | ENSP00000321038 | Isochorismatase domain containing 2 | Lysoplasmalogenase; Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties; Belongs to the TMEM86 family | 0.586 |
ISOC2 | ZNF579 | ENSP00000085068 | ENSP00000320188 | Isochorismatase domain containing 2 | Zinc finger protein 579; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.677 |
IZUMO3 | ISOC2 | ENSP00000474246 | ENSP00000085068 | Izumo sperm-egg fusion protein 3; IZUMO family member 3 | Isochorismatase domain containing 2 | 0.633 |
NAT14 | FIZ1 | ENSP00000205194 | ENSP00000221665 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity); Zinc fingers C2H2-type | 0.456 |
NAT14 | ISOC2 | ENSP00000205194 | ENSP00000085068 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases | Isochorismatase domain containing 2 | 0.614 |
NAT14 | PPP6R1 | ENSP00000205194 | ENSP00000414202 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.439 |
NAT14 | RDH13 | ENSP00000205194 | ENSP00000391121 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases | Retinol dehydrogenase 13; Does not exhibit retinol dehydrogenase (RDH) activity in vitro; Short chain dehydrogenase/reductase superfamily | 0.448 |
NAT14 | ZNF579 | ENSP00000205194 | ENSP00000320188 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases | Zinc finger protein 579; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.571 |