node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA11 | CYP24A1 | ENSP00000084798 | ENSP00000216862 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | 0.669 |
CA11 | KCNJ14 | ENSP00000084798 | ENSP00000375756 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | 0.529 |
CA11 | NTN5 | ENSP00000084798 | ENSP00000270235 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Netrin-5; Netrin 5; Netrins | 0.528 |
CA11 | SLC4A4 | ENSP00000084798 | ENSP00000393557 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+)-HCO3(-) stoichiometry varying from 1-2 to 1-3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family | 0.589 |
CA11 | SLC9A1 | ENSP00000084798 | ENSP00000263980 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | 0.557 |
CA11 | SNRPB | ENSP00000084798 | ENSP00000412566 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Small nuclear ribonucleoprotein-associated proteins B and B; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.641 |
CA11 | THRA | ENSP00000084798 | ENSP00000264637 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Thyroid hormone receptor alpha; Isoform Alpha-1- Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily | 0.565 |
CA11 | THRSP | ENSP00000084798 | ENSP00000281030 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Thyroid hormone-inducible hepatic protein; Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB | 0.720 |
CA11 | TXNRD2 | ENSP00000084798 | ENSP00000383365 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Thioredoxin reductase 2, mitochondrial; Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family | 0.544 |
CA11 | UHMK1 | ENSP00000084798 | ENSP00000420270 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.559 |
CYP24A1 | CA11 | ENSP00000216862 | ENSP00000084798 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | 0.669 |
CYP24A1 | UHMK1 | ENSP00000216862 | ENSP00000420270 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product; Cytochrome P450 family 24 | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.623 |
KCNJ14 | CA11 | ENSP00000375756 | ENSP00000084798 | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | 0.529 |
KCNJ14 | NTN5 | ENSP00000375756 | ENSP00000270235 | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | Netrin-5; Netrin 5; Netrins | 0.551 |
NTN5 | CA11 | ENSP00000270235 | ENSP00000084798 | Netrin-5; Netrin 5; Netrins | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | 0.528 |
NTN5 | KCNJ14 | ENSP00000270235 | ENSP00000375756 | Netrin-5; Netrin 5; Netrins | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | 0.551 |
SLC4A4 | CA11 | ENSP00000393557 | ENSP00000084798 | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+)-HCO3(-) stoichiometry varying from 1-2 to 1-3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | 0.589 |
SLC4A4 | SLC9A1 | ENSP00000393557 | ENSP00000263980 | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+)-HCO3(-) stoichiometry varying from 1-2 to 1-3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | 0.752 |
SLC9A1 | CA11 | ENSP00000263980 | ENSP00000084798 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases | 0.557 |
SLC9A1 | SLC4A4 | ENSP00000263980 | ENSP00000393557 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+)-HCO3(-) stoichiometry varying from 1-2 to 1-3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family | 0.752 |