node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FCHSD2 | RELT | ENSP00000386722 | ENSP00000064780 | FCH and double SH3 domains 2; F-BAR domain containing | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | 0.597 |
HSPA13 | RELT | ENSP00000285667 | ENSP00000064780 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | 0.669 |
LTB | RELT | ENSP00000410481 | ENSP00000064780 | Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional; Tumor necrosis factor superfamily | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | 0.557 |
LTB | TIMD4 | ENSP00000410481 | ENSP00000274532 | Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional; Tumor necrosis factor superfamily | T-cell immunoglobulin and mucin domain-containing protein 4; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity); Belongs to the immunoglobulin superfamily. TIM family | 0.491 |
OXSR1 | RELL1 | ENSP00000311713 | ENSP00000398778 | Serine/threonine-protein kinase OSR1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | RELT-like protein 1; RELT family; Belongs to the RELT family | 0.873 |
OXSR1 | RELL2 | ENSP00000311713 | ENSP00000297164 | Serine/threonine-protein kinase OSR1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | RELT-like protein 2; RELT family | 0.912 |
OXSR1 | RELT | ENSP00000311713 | ENSP00000064780 | Serine/threonine-protein kinase OSR1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | 0.988 |
PIK3R3 | RELT | ENSP00000262741 | ENSP00000064780 | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1 | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | 0.768 |
RELL1 | OXSR1 | ENSP00000398778 | ENSP00000311713 | RELT-like protein 1; RELT family; Belongs to the RELT family | Serine/threonine-protein kinase OSR1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | 0.873 |
RELL1 | RELL2 | ENSP00000398778 | ENSP00000297164 | RELT-like protein 1; RELT family; Belongs to the RELT family | RELT-like protein 2; RELT family | 0.542 |
RELL1 | RELT | ENSP00000398778 | ENSP00000064780 | RELT-like protein 1; RELT family; Belongs to the RELT family | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | 0.555 |
RELL1 | STK39 | ENSP00000398778 | ENSP00000348278 | RELT-like protein 1; RELT family; Belongs to the RELT family | STE20/SPS1-related proline-alanine-rich protein kinase; May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation | 0.530 |
RELL1 | TRAF1 | ENSP00000398778 | ENSP00000362994 | RELT-like protein 1; RELT family; Belongs to the RELT family | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2; TNF receptor associated factors | 0.426 |
RELL2 | OXSR1 | ENSP00000297164 | ENSP00000311713 | RELT-like protein 2; RELT family | Serine/threonine-protein kinase OSR1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | 0.912 |
RELL2 | RELL1 | ENSP00000297164 | ENSP00000398778 | RELT-like protein 2; RELT family | RELT-like protein 1; RELT family; Belongs to the RELT family | 0.542 |
RELL2 | RELT | ENSP00000297164 | ENSP00000064780 | RELT-like protein 2; RELT family | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | 0.759 |
RELL2 | STK39 | ENSP00000297164 | ENSP00000348278 | RELT-like protein 2; RELT family | STE20/SPS1-related proline-alanine-rich protein kinase; May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation | 0.753 |
RELL2 | TRAF1 | ENSP00000297164 | ENSP00000362994 | RELT-like protein 2; RELT family | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2; TNF receptor associated factors | 0.426 |
RELT | FCHSD2 | ENSP00000064780 | ENSP00000386722 | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | FCH and double SH3 domains 2; F-BAR domain containing | 0.597 |
RELT | HSPA13 | ENSP00000064780 | ENSP00000285667 | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | 0.669 |