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  • 11.0 [archived version]
STRINGSTRING
LTB LTB TIMD4 TIMD4 FCHSD2 FCHSD2 STK39 STK39 TRAF1 TRAF1 RELT RELT RELL1 RELL1 PIK3R3 PIK3R3 RELL2 RELL2 OXSR1 OXSR1 HSPA13 HSPA13
"RELT" - Tumor necrosis factor receptor superfamily member 19L in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
RELTTumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family (430 aa)    
Predicted Functional Partners:
OXSR1
Serine/threonine-protein kinase OSR1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily (527 aa)
       
 
  0.988
TRAF1
TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2; TNF receptor associated factors (416 aa)
     
 
  0.923
STK39
STE20/SPS1-related proline-alanine-rich protein kinase; May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (545 aa)
       
 
  0.825
PIK3R3
Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1 (461 aa)
       
      0.768
RELL2
RELT-like protein 2; RELT family (303 aa)
     
 
0.759
HSPA13
Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins (471 aa)
           
  0.669
FCHSD2
FCH and double SH3 domains 2; F-BAR domain containing (740 aa)
     
   
  0.597
TIMD4
T-cell immunoglobulin and mucin domain-containing protein 4; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity); Belongs to the immunoglobulin superfamily. TIM family (378 aa)
           
  0.559
LTB
Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional; Tumor necrosis factor superfamily (244 aa)
     
   
  0.557
RELL1
RELT-like protein 1; RELT family; Belongs to the RELT family (271 aa)
     
 
0.555
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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