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  • 11.0 [archived version]
STRINGSTRING
NMBR NMBR EDN1 EDN1 UTS2R UTS2R UTS2B UTS2B EDN2 EDN2 NPS NPS NTS NTS UTS2 UTS2 HCRT HCRT MCHR2 MCHR2 NMU NMU
"UTS2" - Urotensin 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
Coexpression
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[Homology]
Score
UTS2Urotensin 2; Endogenous ligands (139 aa)    
Predicted Functional Partners:
UTS2R
Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (389 aa)
        
  0.994
UTS2B
Urotensin-2B; Potent vasoconstrictor; Endogenous ligands (119 aa)
      
 
  0.982
EDN1
Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family (212 aa)
          
  0.958
MCHR2
Melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis (340 aa)
          
  0.956
NPS
Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands (89 aa)
          
  0.933
NTS
Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family (170 aa)
      
 
  0.933
NMU
Neuromedin-U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder; Belongs to the NmU family (174 aa)
      
 
  0.931
NMBR
Neuromedin-B receptor; Receptor for neuromedin-B; Bombesin receptors (390 aa)
      
 
  0.930
EDN2
Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands (178 aa)
          
  0.929
HCRT
Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity; Endogenous ligands (131 aa)
          
  0.920
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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