| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| B4GALT7 | DCN | ENSP00000029410 | ENSP00000052754 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | 0.940 |
| B4GALT7 | GPC1 | ENSP00000029410 | ENSP00000264039 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-med [...] | 0.923 |
| B4GALT7 | GPC2 | ENSP00000029410 | ENSP00000292377 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Glypicans | 0.930 |
| B4GALT7 | GPC4 | ENSP00000029410 | ENSP00000359864 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity); Belongs to the glypican family | 0.920 |
| B4GALT7 | GPC5 | ENSP00000029410 | ENSP00000366267 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Glypican-5; Cell surface proteoglycan that bears heparan sulfate; Belongs to the glypican family | 0.925 |
| B4GALT7 | GPC6 | ENSP00000029410 | ENSP00000366246 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling; Belongs to the glypican family | 0.915 |
| B4GALT7 | NCAN | ENSP00000029410 | ENSP00000252575 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Neurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid; Belongs to the aggrecan/versican proteoglycan family | 0.900 |
| B4GALT7 | SDC2 | ENSP00000029410 | ENSP00000307046 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Syndecan-2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity); CD molecules | 0.915 |
| B4GALT7 | SDC4 | ENSP00000029410 | ENSP00000361818 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP; Belongs to the syndecan proteoglycan family | 0.909 |
| B4GALT7 | XYLT2 | ENSP00000029410 | ENSP00000017003 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | Xylosyltransferase 2; Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans. Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated; Belongs to the glycosyltransferase 14 family. XylT subfamily | 0.977 |
| DCN | B4GALT7 | ENSP00000052754 | ENSP00000029410 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family | 0.940 |
| DCN | GPC1 | ENSP00000052754 | ENSP00000264039 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-med [...] | 0.958 |
| DCN | GPC2 | ENSP00000052754 | ENSP00000292377 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Glypicans | 0.947 |
| DCN | GPC4 | ENSP00000052754 | ENSP00000359864 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity); Belongs to the glypican family | 0.944 |
| DCN | GPC5 | ENSP00000052754 | ENSP00000366267 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-5; Cell surface proteoglycan that bears heparan sulfate; Belongs to the glypican family | 0.944 |
| DCN | GPC6 | ENSP00000052754 | ENSP00000366246 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling; Belongs to the glypican family | 0.946 |
| DCN | NCAN | ENSP00000052754 | ENSP00000252575 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Neurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid; Belongs to the aggrecan/versican proteoglycan family | 0.953 |
| DCN | SDC2 | ENSP00000052754 | ENSP00000307046 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Syndecan-2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity); CD molecules | 0.951 |
| DCN | SDC4 | ENSP00000052754 | ENSP00000361818 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP; Belongs to the syndecan proteoglycan family | 0.952 |
| DCN | XYLT2 | ENSP00000052754 | ENSP00000017003 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Xylosyltransferase 2; Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans. Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated; Belongs to the glycosyltransferase 14 family. XylT subfamily | 0.924 |
