| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BTBD11 | C12orf5 | ENSP00000280758 | ENSP00000179259 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | 0.582 |
| BTBD11 | PPFIBP1 | ENSP00000280758 | ENSP00000314724 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing | 0.781 |
| BTBD11 | TSPAN9 | ENSP00000280758 | ENSP00000011898 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.654 |
| C12orf5 | BTBD11 | ENSP00000179259 | ENSP00000280758 | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | 0.582 |
| C12orf5 | PPFIBP1 | ENSP00000179259 | ENSP00000314724 | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing | 0.551 |
| C12orf5 | TSPAN9 | ENSP00000179259 | ENSP00000011898 | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.651 |
| CDX2 | TEAD1 | ENSP00000370408 | ENSP00000435233 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | Transcriptional enhancer factor TEF-1; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | 0.406 |
| CDX2 | TSPAN9 | ENSP00000370408 | ENSP00000011898 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.626 |
| PPFIBP1 | BTBD11 | ENSP00000314724 | ENSP00000280758 | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | 0.781 |
| PPFIBP1 | C12orf5 | ENSP00000314724 | ENSP00000179259 | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | 0.551 |
| PPFIBP1 | TSPAN9 | ENSP00000314724 | ENSP00000011898 | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.699 |
| RFESD | RPS27 | ENSP00000413592 | ENSP00000357555 | Rieske domain-containing protein; Rieske Fe-S domain containing | 40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family | 0.419 |
| RFESD | THAP3 | ENSP00000413592 | ENSP00000054650 | Rieske domain-containing protein; Rieske Fe-S domain containing | THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1; THAP domain containing | 0.663 |
| RFESD | TSPAN9 | ENSP00000413592 | ENSP00000011898 | Rieske domain-containing protein; Rieske Fe-S domain containing | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.615 |
| RPS27 | RFESD | ENSP00000357555 | ENSP00000413592 | 40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family | Rieske domain-containing protein; Rieske Fe-S domain containing | 0.419 |
| RPS27 | THAP3 | ENSP00000357555 | ENSP00000054650 | 40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family | THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1; THAP domain containing | 0.428 |
| RPS27 | TSPAN9 | ENSP00000357555 | ENSP00000011898 | 40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.670 |
| TEAD1 | CDX2 | ENSP00000435233 | ENSP00000370408 | Transcriptional enhancer factor TEF-1; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | 0.406 |
| TEAD1 | TEAD3 | ENSP00000435233 | ENSP00000345772 | Transcriptional enhancer factor TEF-1; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | 0.916 |
| TEAD1 | TSPAN9 | ENSP00000435233 | ENSP00000011898 | Transcriptional enhancer factor TEF-1; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.648 |
