| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BTG3 | NIPAL4 | ENSP00000344609 | ENSP00000311687 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway | 0.588 |
| BTG3 | PI4K2B | ENSP00000344609 | ENSP00000264864 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Phosphatidylinositol 4-kinase type 2-beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the [...] | 0.582 |
| BTG3 | YBX2 | ENSP00000344609 | ENSP00000007699 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] | 0.645 |
| FIGLA | LHX8 | ENSP00000333097 | ENSP00000294638 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | 0.862 |
| FIGLA | NOBOX | ENSP00000333097 | ENSP00000419457 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | 0.881 |
| FIGLA | SOHLH1 | ENSP00000333097 | ENSP00000404438 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development; Basic helix-loop-helix proteins | 0.804 |
| FIGLA | YBX2 | ENSP00000333097 | ENSP00000007699 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] | 0.756 |
| FIGLA | ZP2 | ENSP00000333097 | ENSP00000460971 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Zona pellucida sperm-binding protein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.774 |
| LHX8 | FIGLA | ENSP00000294638 | ENSP00000333097 | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | 0.862 |
| LHX8 | NOBOX | ENSP00000294638 | ENSP00000419457 | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | 0.816 |
| LHX8 | SOHLH1 | ENSP00000294638 | ENSP00000404438 | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development; Basic helix-loop-helix proteins | 0.939 |
| LHX8 | YBX2 | ENSP00000294638 | ENSP00000007699 | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] | 0.749 |
| NIPAL4 | BTG3 | ENSP00000311687 | ENSP00000344609 | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | 0.588 |
| NIPAL4 | PI4K2B | ENSP00000311687 | ENSP00000264864 | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway | Phosphatidylinositol 4-kinase type 2-beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the [...] | 0.714 |
| NIPAL4 | YBX2 | ENSP00000311687 | ENSP00000007699 | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] | 0.617 |
| NOBOX | FIGLA | ENSP00000419457 | ENSP00000333097 | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | 0.881 |
| NOBOX | LHX8 | ENSP00000419457 | ENSP00000294638 | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | 0.816 |
| NOBOX | SOHLH1 | ENSP00000419457 | ENSP00000404438 | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development; Basic helix-loop-helix proteins | 0.726 |
| NOBOX | YBX2 | ENSP00000419457 | ENSP00000007699 | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] | 0.653 |
| NOBOX | ZP2 | ENSP00000419457 | ENSP00000460971 | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | Zona pellucida sperm-binding protein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.675 |
