OSBPL7 protein (human) - STRING database

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OSBPL7

Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family (842 aa)

Predicted Functional Partners:

VAPA

0.828

PRR15L

0.774

PNPO

0.720

TBKBP1

0.713

NFE2L1

0.694

VAPB

0.681

TYW1B

0.670

PYCRL

0.573

PLEK

0.556

ABCA8

0.543

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA8	OSBPL7	ENSP00000467271	ENSP00000007414	ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter; ATP binding cassette subfamily A	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	0.543
ABCA8	TYW1B	ENSP00000467271	ENSP00000482502	ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter; ATP binding cassette subfamily A	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N- methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)	0.567
NFE2L1	OSBPL7	ENSP00000354855	ENSP00000007414	Nuclear factor erythroid 2-related factor 1; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	0.694
NFE2L1	PNPO	ENSP00000354855	ENSP00000225573	Nuclear factor erythroid 2-related factor 1; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins	Pyridoxine-5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP)	0.659
NFE2L1	PRR15L	ENSP00000354855	ENSP00000300557	Nuclear factor erythroid 2-related factor 1; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins	Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family	0.696
NFE2L1	TBKBP1	ENSP00000354855	ENSP00000354777	Nuclear factor erythroid 2-related factor 1; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins	TANK-binding kinase 1-binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity	0.697
OSBPL7	ABCA8	ENSP00000007414	ENSP00000467271	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter; ATP binding cassette subfamily A	0.543
OSBPL7	NFE2L1	ENSP00000007414	ENSP00000354855	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Nuclear factor erythroid 2-related factor 1; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins	0.694
OSBPL7	PLEK	ENSP00000007414	ENSP00000234313	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Pleckstrin; Major protein kinase C substrate of platelets; Pleckstrin homology domain containing	0.556
OSBPL7	PNPO	ENSP00000007414	ENSP00000225573	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Pyridoxine-5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP)	0.720
OSBPL7	PRR15L	ENSP00000007414	ENSP00000300557	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family	0.774
OSBPL7	PYCRL	ENSP00000007414	ENSP00000220966	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline	0.573
OSBPL7	TBKBP1	ENSP00000007414	ENSP00000354777	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	TANK-binding kinase 1-binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity	0.713
OSBPL7	TYW1B	ENSP00000007414	ENSP00000482502	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N- methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)	0.670
OSBPL7	VAPA	ENSP00000007414	ENSP00000345656	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A	0.828
OSBPL7	VAPB	ENSP00000007414	ENSP00000417175	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Vesicle-associated membrane protein-associated protein B/C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation	0.681
PLEK	OSBPL7	ENSP00000234313	ENSP00000007414	Pleckstrin; Major protein kinase C substrate of platelets; Pleckstrin homology domain containing	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	0.556
PNPO	NFE2L1	ENSP00000225573	ENSP00000354855	Pyridoxine-5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP)	Nuclear factor erythroid 2-related factor 1; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins	0.659
PNPO	OSBPL7	ENSP00000225573	ENSP00000007414	Pyridoxine-5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP)	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	0.720
PNPO	PRR15L	ENSP00000225573	ENSP00000300557	Pyridoxine-5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP)	Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family	0.732

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