node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPN3 | PPP6R3 | ENSP00000268933 | ENSP00000377390 | Epsin-3; Epsin 3; Belongs to the epsin family | Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance; Belongs to the SAPS family | 0.403 |
EPN3 | SPATA20 | ENSP00000268933 | ENSP00000006658 | Epsin-3; Epsin 3; Belongs to the epsin family | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.547 |
NDUFV2 | SPATA20 | ENSP00000327268 | ENSP00000006658 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity); NADH-ubiquinone oxidoreductase core subunits | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.534 |
PPP6R3 | EPN3 | ENSP00000377390 | ENSP00000268933 | Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance; Belongs to the SAPS family | Epsin-3; Epsin 3; Belongs to the epsin family | 0.403 |
PPP6R3 | SPATA20 | ENSP00000377390 | ENSP00000006658 | Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance; Belongs to the SAPS family | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.514 |
RSBN1 | SPAG7 | ENSP00000261441 | ENSP00000206020 | Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated ’Lys-20’ of histone H4 (H4K20me2), thereby modulating chromosome architecture; Belongs to the round spermatid basic protein 1 family | Sperm associated antigen 7 | 0.574 |
RSBN1 | SPATA20 | ENSP00000261441 | ENSP00000006658 | Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated ’Lys-20’ of histone H4 (H4K20me2), thereby modulating chromosome architecture; Belongs to the round spermatid basic protein 1 family | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.597 |
SAT2 | SPATA20 | ENSP00000269298 | ENSP00000006658 | Diamine acetyltransferase 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine; GCN5 related N-acetyltransferases | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.534 |
SNF8 | SPATA20 | ENSP00000421380 | ENSP00000006658 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with [...] | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.535 |
SNF8 | UBE2Z | ENSP00000421380 | ENSP00000354201 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with [...] | Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation; Ubiquitin conjugating enzymes E2 | 0.632 |
SPAG7 | RSBN1 | ENSP00000206020 | ENSP00000261441 | Sperm associated antigen 7 | Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated ’Lys-20’ of histone H4 (H4K20me2), thereby modulating chromosome architecture; Belongs to the round spermatid basic protein 1 family | 0.574 |
SPAG7 | SPATA20 | ENSP00000206020 | ENSP00000006658 | Sperm associated antigen 7 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.633 |
SPATA12 | SPATA20 | ENSP00000335392 | ENSP00000006658 | Spermatogenesis-associated protein 12; Spermatogenesis associated 12 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | 0.473 |
SPATA20 | EPN3 | ENSP00000006658 | ENSP00000268933 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | Epsin-3; Epsin 3; Belongs to the epsin family | 0.547 |
SPATA20 | NDUFV2 | ENSP00000006658 | ENSP00000327268 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity); NADH-ubiquinone oxidoreductase core subunits | 0.534 |
SPATA20 | PPP6R3 | ENSP00000006658 | ENSP00000377390 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance; Belongs to the SAPS family | 0.514 |
SPATA20 | RSBN1 | ENSP00000006658 | ENSP00000261441 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated ’Lys-20’ of histone H4 (H4K20me2), thereby modulating chromosome architecture; Belongs to the round spermatid basic protein 1 family | 0.597 |
SPATA20 | SAT2 | ENSP00000006658 | ENSP00000269298 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | Diamine acetyltransferase 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine; GCN5 related N-acetyltransferases | 0.534 |
SPATA20 | SNF8 | ENSP00000006658 | ENSP00000421380 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with [...] | 0.535 |
SPATA20 | SPAG7 | ENSP00000006658 | ENSP00000206020 | Spermatogenesis-associated protein 20; May play a role in fertility regulation | Sperm associated antigen 7 | 0.633 |