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STRINGSTRING
PTN PTN MDK MDK NTM NTM LDB3 LDB3 ADAMTS16 ADAMTS16 PXN PXN ADAMTS8 ADAMTS8 SPON2 SPON2 TGFB1I1 TGFB1I1 ADAMTS17 ADAMTS17 ADAMTS19 ADAMTS19 ADAMTS10 ADAMTS10 ADAMTS2 ADAMTS2 THSD7B THSD7B TAGLN2 TAGLN2 TAGLN3 TAGLN3 ADAMTS1 ADAMTS1 ADAMTS18 ADAMTS18 THBS1 THBS1 CNN1 CNN1 THSD1 THSD1 TAGLN TAGLN CFP CFP PAPLN PAPLN CNN2 CNN2 CNN3 CNN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CFPProperdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes (469 aa)
ADAMTS2A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis; ADAM metallopeptidases with thrombospondin type 1 motif (1211 aa)
CNN1Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity) (297 aa)
ADAMTS8A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties; ADAM metallopeptidases with thrombospondin type 1 motif (889 aa)
THSD1Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1 (852 aa)
THBS1Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity) (1170 aa)
CNN2Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (309 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion); Belongs to the paxillin family (605 aa)
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17 (1095 aa)
ADAMTS10A disintegrin and metalloproteinase with thrombospondin motifs 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues; ADAM metallopeptidases with thrombospondin type 1 motif (1103 aa)
THSD7BThrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B (1608 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16 (1224 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19 (1207 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18 (1221 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the ’1938-Glu-|-Leu-1939’ site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif (967 aa)
PTNPleiotrophin; Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Binds to cell-surface target proteins via their chondroitin sulfate groups. Down-regulates PTPRZ1 activity; Belongs to the pleiotrophin family (168 aa)
PAPLNPapilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family (1251 aa)
TAGLN2Transgelin-2; Transgelin 2 (220 aa)
CNN3Calponin-3; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (329 aa)
TAGLN3Transgelin-3; Transgelin 3 (199 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. [...] (461 aa)
MDKMidkine; Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity) (143 aa)
NTMNeurotrimin; Neural cell adhesion molecule; Belongs to the immunoglobulin superfamily. IgLON family (355 aa)
LDB3LIM domain-binding protein 3; LIM domain containing (732 aa)
TAGLNTransgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence; Belongs to the calponin family (201 aa)
SPON2Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) (331 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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