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| PKP2 | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing (881 aa) | |||
| TGM1 | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family (817 aa) | |||
| CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (295 aa) | |||
| PI3 | Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing (117 aa) | |||
| DSG3 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins (999 aa) | |||
| DSG1 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins (1049 aa) | |||
| DSC1 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins (894 aa) | |||
| DSG2 | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins (1118 aa) | |||
| PKP1 | Plakophilin-1; Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis; Armadillo repeat containing (747 aa) | |||
| CSTA | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family (98 aa) | |||
| DSC2 | Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins (901 aa) | |||
| EVPL | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins (2033 aa) | |||
| SPRR1B | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family (89 aa) | |||
| OAZ3 | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] (190 aa) | |||
| LCE1D | Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum (114 aa) | |||
| RPTN | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing (784 aa) | |||
| SPRR3 | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins (169 aa) | |||
| PKP3 | Plakophilin-3; May play a role in junctional plaques; Armadillo repeat containing (797 aa) | |||
| LCE5A | Late cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (118 aa) | |||
| LCE1F | Late cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum (118 aa) | |||
| LCE3C | Late cornified envelope protein 3C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (94 aa) | |||
| LCE1A | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum (110 aa) | |||
| LCE3A | Late cornified envelope protein 3A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (89 aa) | |||
| TBC1D14 | TBC1 domain family member 14; Negative regulator of starvation-induced autophagosome formation (693 aa) | |||
| NSMAF | Protein FAN; Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE; BEACH domain containing (948 aa) | |||
| TCHH | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation; EF-hand domain containing (1943 aa) | |||
