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  • 11.0 [archived version]
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RPA3 RPA3 RPA1 RPA1 LTN1 LTN1 RPL8 RPL8 RPL12 RPL12 RPL39 RPL39 RPL15 RPL15 RPL9 RPL9 RPL21 RPL21 RPL30 RPL30 RPL17 RPL17 RPL38 RPL38 RPL11 RPL11 RPL10L RPL10L RPL23 RPL23 RPL24 RPL24 RPL37 RPL37 RPL37A RPL37A RPL34 RPL34 RPL35A RPL35A RPLP0 RPLP0 RPL32 RPL32 RPL36 RPL36 SEC61B SEC61B RPL23A RPL23A RPL27 RPL27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A 14 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP [...] (121 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SEC61-beta family (96 aa)
RPA1Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruit [...] (616 aa)
RPL860S ribosomal protein L8; Component of the large ribosomal subunit (257 aa)
RPL3760S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins (97 aa)
RPL10L60S ribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis; L ribosomal proteins (214 aa)
RPL15Ribosomal protein L15 (204 aa)
RPL38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family (70 aa)
RPL2160S ribosomal protein L21; Component of the large ribosomal subunit (160 aa)
RPL1260S ribosomal protein L12; Binds directly to 26S ribosomal RNA (165 aa)
RPL39Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family (51 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] (178 aa)
RPL24Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family (157 aa)
RPL3460S ribosomal protein L34; Component of the large ribosomal subunit (117 aa)
RPL23A60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family (156 aa)
RPL1760S ribosomal protein L17; Component of the large ribosomal subunit; Belongs to the universal ribosomal protein uL22 family (184 aa)
RPL9L ribosomal proteins (192 aa)
RPL32Ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family (135 aa)
RPL37ARibosomal protein L37a (92 aa)
RPL35A60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (110 aa)
RPL23Ribosomal protein L23 (140 aa)
RPL30Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family (115 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (317 aa)
RPL3660S ribosomal protein L36; Component of the large ribosomal subunit (105 aa)
RPL2760S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (136 aa)
LTN1E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity); Armadillo-like helical domain containing (1812 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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