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  • 11.0 [archived version]
STRINGSTRING
TBC1D17 TBC1D17 TBC1D28 TBC1D28 TBC1D14 TBC1D14 TBC1D26 TBC1D26 TBC1D8B TBC1D8B TBC1D5 TBC1D5 GRTP1 GRTP1 TBC1D16 TBC1D16 TBC1D8 TBC1D8 TBC1D25 TBC1D25 TBC1D9B TBC1D9B RABGAP1 RABGAP1 TBC1D2B TBC1D2B TBC1D13 TBC1D13 SGSM3 SGSM3 TBC1D21 TBC1D21 SGSM1 SGSM1 TBC1D10B TBC1D10B TBC1D12 TBC1D12 SGSM2 SGSM2 RABGAP1L RABGAP1L USP6NL USP6NL TBC1D10A TBC1D10A ENSG00000248751 ENSG00000248751 ICA1L ICA1L PICK1 PICK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBC1D17TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known (648 aa)
TBC1D12TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) (775 aa)
SGSM3Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells; Small G protein signaling modulators (749 aa)
RABGAP1LRab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A- GDP. Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous dir [...] (815 aa)
SGSM2Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation; Belongs to the RUTBC family (1051 aa)
USP6NLUSP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (845 aa)
TBC1D21TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (336 aa)
TBC1D2BTBC1 domain family member 2B; May act as a GTPase-activating protein (963 aa)
TBC1D16TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s) (767 aa)
TBC1D28TBC1 domain family member 28 (210 aa)
TBC1D9BTBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing (1250 aa)
TBC1D8BTBC1 domain family member 8B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing (1120 aa)
TBC1D13TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (400 aa)
RABGAP1Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition (1069 aa)
GRTP1Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) (344 aa)
TBC1D25TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes (688 aa)
TBC1D8TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s); GRAM domain containing (1140 aa)
SGSM1Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family (1148 aa)
TBC1D10ATBC1 domain family member 10A; Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A (515 aa)
PICK1PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] (415 aa)
TBC1D10BTBC1 domain family member 10B; Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A (808 aa)
TBC1D14TBC1 domain family member 14; Negative regulator of starvation-induced autophagosome formation (693 aa)
ENSG00000248751Uncharacterized protein (480 aa)
TBC1D5TBC1 domain family member 5; May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogrammin [...] (817 aa)
TBC1D26TBC1 domain family member 26; May act as a GTPase-activating protein for Rab family protein(s); Belongs to the krueppel C2H2-type zinc-finger protein family (250 aa)
ICA1LIslet cell autoantigen 1-like protein; Classical BAR domain containing (482 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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