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  • 11.0 [archived version]
STRINGSTRING
LCE5A LCE5A LCE1F LCE1F LCE3A LCE3A LCE4A LCE4A LCE1A LCE1A LCE1C LCE1C VASN VASN LCE2B LCE2B LCE2D LCE2D LCE1D LCE1D LCE1B LCE1B TGFB1 TGFB1 LCE2A LCE2A LCE2C LCE2C LCE3B LCE3B CRCT1 CRCT1 FBLN1 FBLN1 KRTAP5-4 KRTAP5-4 KRTAP10-5 KRTAP10-5 OIT3 OIT3 KRTAP4-12 KRTAP4-12 KRTAP5-11 KRTAP5-11 KRTAP5-3 KRTAP5-3 NTN4 NTN4 KRTAP4-2 KRTAP4-2 KRTAP4-5 KRTAP4-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...] (390 aa)
VASNVasorin; May act as an inhibitor of TGF-beta signaling (673 aa)
LCE1DLate cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum (114 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a signi [...] (703 aa)
OIT3Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development (545 aa)
LCE5ALate cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (118 aa)
LCE1FLate cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum (118 aa)
LCE1ALate cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE3ALate cornified envelope protein 3A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (89 aa)
LCE3BLate cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (95 aa)
KRTAP4-5Keratin-associated protein 4-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (181 aa)
NTN4Netrin-4; May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants; Netrins (628 aa)
LCE1BLate cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum (118 aa)
LCE4ALate cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (99 aa)
LCE2ALate cornified envelope protein 2A; Precursors of the cornified envelope of the stratum corneum (106 aa)
LCE2BLate cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE2CLate cornified envelope protein 2C; Precursors of the cornified envelope of the stratum (110 aa)
LCE2DLate cornified envelope protein 2D; Precursors of the cornified envelope of the stratum corneum (110 aa)
CRCT1Cysteine rich C-terminal 1 (99 aa)
KRTAP4-2Keratin-associated protein 4-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (136 aa)
KRTAP4-12Keratin-associated protein 4-12; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (201 aa)
KRTAP5-11Keratin-associated protein 5-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family (156 aa)
KRTAP5-4Keratin associated protein 5-4 (228 aa)
KRTAP5-3Keratin-associated protein 5-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family (238 aa)
KRTAP10-5Keratin-associated protein 10-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family (271 aa)
LCE1CLate cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum (118 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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