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  • 11.0 [archived version]
STRINGSTRING
GOLGA8O GOLGA8O GOLGA6B GOLGA6B GOLGA8N GOLGA8N GOLGA6D GOLGA6D POMGNT2 POMGNT2 GOLGA2 GOLGA2 NRF1 NRF1 GOLGA8F GOLGA8F GOLGA8A GOLGA8A GOLGA8K GOLGA8K USO1 USO1 RPL22L1 RPL22L1 RPL22 RPL22 GOLGA8B GOLGA8B GOLGA6C GOLGA6C EOGT EOGT GOLGA6A GOLGA6A NAGA NAGA FKBP15 FKBP15 GOLGA8R GOLGA8R GOLGA6L2 GOLGA6L2 GOLGA6L4 GOLGA6L4 MPPE1 MPPE1 GOLGA8S GOLGA8S ENSG00000269590 ENSG00000269590 GLA GLA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLAGalactosidase alpha; Belongs to the glycosyl hydrolase 27 family (429 aa)
FKBP15FK506-binding protein 15; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement; FKBP prolyl isomerases (1219 aa)
GOLGA6AGolgin A6 family member A; Belongs to the GOLGA6 family (693 aa)
GOLGA6CGolgin A6 family member C; Belongs to the GOLGA6 family (693 aa)
GOLGA8RGolgin A8 family member R (631 aa)
GOLGA8BGolgin subfamily A member 8B; May be involved in maintaining Golgi structure; Belongs to the GOLGA8 family (603 aa)
POMGNT2Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that transfers UDP-N-acetyl-D- glucosamine to the 4-position of the mannose to generate N-acetyl- D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (580 aa)
RPL22L1Ribosomal protein L22 like 1; Belongs to the eukaryotic ribosomal protein eL22 family (122 aa)
RPL22Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family (128 aa)
GOLGA8AGolgin subfamily A member 8A; May be involved in maintaining Golgi structure (603 aa)
EOGTEGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains; O-linked N-acetylglucosaminyltransferases (527 aa)
NRF1Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (503 aa)
NAGAAlpha-N-acetylgalactosaminidase; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (411 aa)
GOLGA6DGolgin A6 family member D; Belongs to the GOLGA6 family (693 aa)
GOLGA8NGolgin A8 family member N; Belongs to the GOLGA8 family (632 aa)
GOLGA6BGolgin A6 family member B; Belongs to the GOLGA6 family (693 aa)
GOLGA2Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...] (1002 aa)
GOLGA6L4Golgin subfamily A member 6-like protein 4; Golgin A6 family-like 4; Belongs to the GOLGA6 family (574 aa)
GOLGA8OGolgin A8 family member O; Belongs to the GOLGA6 family (632 aa)
GOLGA8KGolgin A8 family member K; Belongs to the GOLGA8 family (630 aa)
USO1General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Armadillo-like helical domain containing (962 aa)
GOLGA8FGolgin A8 family member F; Belongs to the GOLGA8 family (648 aa)
GOLGA6L2Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family (909 aa)
GOLGA8SGolgin A8 family member S (625 aa)
MPPE1Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins; Belongs to the metallophosphoesterase superfamily. MPPE1 family (396 aa)
ENSG00000269590Uncharacterized protein (195 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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